Author

A. P. Joseph

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:dimensionality reduction· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

M. Topf· 2 shared A. Kryshtafovych· 1 shared A. L. B. Pyne· 1 shared A. Menny· 1 shared A. Patwardhan· 1 shared A. Perez· 1 shared A. Singharoy· 1 shared A. Vaiana· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

M. Topf

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

TopoStats - a program for automated tracing of biomolecules from AFM images

J. G. Beton, R. Moorehead, L. Helfmann, R. Gray, B. Hoogenboom, A. P. Joseph, M. Topf, A. L. B. Pyne

TopoStats automatically traces biomolecules in AFM images with high accuracy, identifying 90% of molecules and assemblies without prior processing.

bioRxiv · Sep 23, 2020Biophysics

Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution

C. L. Lawson, A. Kryshtafovych, P. D. Adams, P. Afonine, M. L. Baker, B. A. Barad, P. Bond, T. Burnley, R. Cao, J. Cheng, G. Chojnowski, K. Cowtan, K. A. Dill, F. DiMaio, D. Farrell, , Wan

The paper evaluates cryo-EM model quality using benchmark maps, showing high accuracy and reproducibility across 13 teams and recommending multiple metrics for model assessment.

bioRxiv · Jun 12, 2020Biochemistry

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

A. Menny, M. Serna, C. M. Boyd, S. Gardner, A. P. Joseph, B. P. Morgan, M. Topf, N. J. Brooks, D. Bubeck

This study uses cryo-EM to show how the complement membrane attack complex interacts with lipid bilayers through distinct mechanisms involving C6/C7 and C8/C9, revealing structural insights into pore formation and membrane disruption.

bioRxiv · Aug 17, 2018Biophysics