P. Bond

SARS-CoV-2 S protein ACE2 interaction reveals novel allosteric targets

The paper investigates how ACE2 binding to SARS-CoV-2 Spike protein allosterically affects proteolysis at distal cleavage sites and highlights potential therapeutic targets.

Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution

The paper evaluates cryo-EM model quality using benchmark maps, showing high accuracy and reproducibility across 13 teams and recommending multiple metrics for model assessment.

Non-antibiotic pharmaceuticals can enhance the spread of antibiotic resistance via conjugation

This study shows non-antibiotic pharmaceuticals can increase antibiotic resistance spread via conjugation by enhancing ROS production and cell membrane permeability.

The structural basis for distinct binding avidity of Pertuzumab and Trastuzumab IgM towards HER2

This paper investigates the structural basis for the differing binding avidity of Pertuzumab and Trastuzumab IgM to HER2, showing that Pertuzumab IgM binds more effectively due to stable engagement via all V-regions.