P. Dulyayangkul

Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics

The paper shows that gene cassettes in an integron, amplified by IS26, confer resistance to amikacin and piperacillin/tazobactam, often leaving meropenem as the last-resort antibiotic.

Identification and characterisation of Klebsiella pneumoniae and Pseudomonas aeruginosa clinical isolates with atypical β-lactam susceptibility profiles using Orbitrap liquid chromatography-tandem mass spectrometry

The paper uses proteomics and whole genome sequencing to characterize clinical isolates of Klebsiella pneumoniae and Pseudomonas aeruginosa with atypical β-lactam susceptibility profiles, expanding predictive rules for antibiotic resistance.

Klebsiella pneumoniae mutants resistant to ceftazidime/avibactam plus aztreonam, imipenem/relebactam, meropenem/vaborbactam and cefepime/taniborbactam.

The paper demonstrates that specific mutations in Klebsiella pneumoniae confer resistance to multiple beta-lactam combinations but not cefepime/taniborbactam.

OmpF Downregulation Mediated by Sigma E or OmpR Activation Confers Cefalexin Resistance in Escherichia coli in the Absence of Acquired β-Lactamases.

This study identifies OmpF downregulation via Sigma E or OmpR activation as a mechanism for cefalexin resistance in E. coli without β-lactamase production.

Resistance to aztreonam in combination with non-β-lactam β-lactamase inhibitors due to the layering of mechanisms in Escherichia coli identified following mixed culture selection.

The paper identifies layered resistance mechanisms in Escherichia coli to aztreonam combined with β-lactamase inhibitors through mixed culture selection.

Novel mechanisms of efflux-mediated levofloxacin resistance and reduced amikacin susceptibility in Stenotrophomonas maltophilia.

This study identifies novel efflux pump mechanisms and regulatory systems contributing to levofloxacin resistance and amikacin susceptibility reduction in Stenotrophomonas maltophilia.

Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae.

The paper identifies KvrA mutations that reduce OmpK35/36 porin expression and increase resistance to meropenem/vaborbactam in KPC-producing K. pneumoniae.

Proteomic Investigation of the Signal Transduction Pathways Controlling Colistin Resistance in Klebsiella pneumoniae.

This study uses proteomics to investigate how mutations in MgrB, PhoPQ, and PmrAB affect Arn protein production and colistin resistance in Klebsiella pneumoniae.

Resistance to Ceftazidime/Avibactam Plus Meropenem/Vaborbactam When Both are Used Together Achieved in Four Steps From Metallo-β-Lactamase Negative Klebsiella pneumoniae.

The paper identifies four genetic steps enabling resistance to the combination of ceftazidime/avibactam and meropenem/vaborbactam in K. pneumoniae.

TonB dependent uptake of β-lactam antibiotics in the opportunistic human pathogen Stenotrophomonas maltophilia.

The paper shows that mutations in TonB confer ceftazidime resistance in S. maltophilia, challenging the belief that β-lactams only enter Gram-negative bacteria via passive diffusion.