Author

S. Hildebrand

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

B. Beutler· 2 shared E. M. Y. Moresco· 2 shared A. Khvorova· 1 shared A. Liu· 1 shared A. Pfeifer· 1 shared A. Roebroeck· 1 shared A. Schueth· 1 shared A. Summer· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersImmunology

B. Beutler

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Efficient targeting of heart lesions with cardiac myofibroblasts: Combined gene and cell therapy enhanced by magnetic steering

M. Schiffer, K. Wagner, E. Carls, J. Nicke, M. Hesse, R. Fratila, S. Hildebrand, A. Pfeifer, D. Eberbeck, M. Malek Mohammadi, J. M. de la Fuente, B. K. Fleischmann, W. Roell

The paper develops a method to target cardiac scars using genetically modified myofibroblasts guided by magnetic steering, showing improved engraftment and reduced ventricular tachycardia.

bioRxiv · Feb 16, 2024 · PreprintPhysiology

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

K. Yamada, V. N. Hariharan, J. Caiazzi, R. Miller, C. Ferguson, E. Sapp, H. Fakih, Q. Tan, N. Yamada, R. Furgal, J. Paquette, B. Bramato, N. McHugh, A. Summer, C. Lochmann, , A. Khvorova

This paper introduces exNA, a novel nucleic acid backbone that enhances oligonucleotide stability and efficacy in vivo, showing improved resistance to exonucleases and increased tissue exposure and potency.

bioRxiv · May 26, 2023Biochemistry

De novo germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice

A.-P. Foray, S. Candon, S. Hildebrand, C. Marquet, F. Valette, C. Pecquet, S. Lemoine, F. Langa-Vives, M. Dumas, P. Hu, P. Santamaria, S. Lyon, L. Scott, C. H. Bu, T. Wang, , L. Chatenoud

This study identifies a de novo germline mutation in Dusp10 that accelerates autoimmune diabetes in NOD mice by increasing susceptibility through CRISPR validation and PD-L1 expression analysis.

bioRxiv · Dec 30, 2020 · PreprintImmunology

Mechanism of negative regulation of NF-κB by N4BP1

H. Shi, L. Sun, Y. Wang, A. Liu, X. Zhan, X. Li, M. Tang, P. Anderton, S. Hildebrand, J. Quan, S. Ludwig, E. M. Y. Moresco, B. Beutler

This study identifies N4BP1 as an inhibitor of NF-κB activation by interacting with NEMO, and shows that caspase 8 cleavage inactivates N4BP1 during TRIF-dependent signaling.

bioRxiv · Oct 21, 2020 · PreprintImmunology

Monte Carlo Simulation of Diffusion MRI in geometries constructed from two-photon microscopy of cortical gray matter

N. Gilani, S. Hildebrand, A. Schueth, A. Roebroeck

This study simulates diffusion MRI signals in human cortical tissue using 3D microscopy data to understand how cytoarchitecture affects diffusion metrics like MD and MK.

bioRxiv · Jul 9, 2019 · PreprintBiophysics