A. R. Abate

Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

Microbiome single cell atlases generated with a commercial instrument

The paper introduces EASi-seq, a method for single-cell sequencing of microbes using a commercial platform, enabling detailed microbiome atlases and improved bioinformatic analysis.

Mapping enzyme catalysis with metabolomic biosensing

The paper introduces a method to sense enzyme product formation using host cell metabolism and mass spectrometry to map enzyme activity and mutagenesis effects.

Modular barcode beads for microfluidic single cell genomics

The paper introduces modular barcode beads for single cell genomics, enabling flexible and efficient nucleic acid tagging for RNA and DNA sequencing.

Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia

This study introduces DAb-seq, a method to simultaneously profile DNA and protein in single cells, and applies it to analyze leukemia patient data to reveal genotype-phenotype dynamics.

Linked optical and gene expression profiling of single cells at high throughput

This paper introduces a high-throughput platform that links optical and gene expression profiling of single cells, demonstrating accurate measurements from thousands of cells and characterizing DNA and RNA changes in Jurkat cells through the cell cycle.

Particle-templated emulsification for microfluidics-free digital biology

This paper introduces a method to create monodispersed emulsions for biological applications without using microfluidics, demonstrating its use in ddPCR and single cell culture.

Robotic automation of droplet microfluidics

This paper demonstrates robotically-automated droplet microfluidics to streamline complex workflows, enhancing reliability and convenience through commercial fluid-handling robots.

Combined aptamer and transcriptome sequencing of single cells

The paper introduces a method combining aptamer probes and transcriptome sequencing to simultaneously analyze transcriptomes and proteomes of single cells, enabling cell type differentiation based on binding and expression patterns.

Printed Droplet Microfluidics for on demand dispensing of picoliter droplets and cells

This paper introduces a technology for high-throughput dispensing of picoliter droplets and cells with deterministic control, enabling precise array generation and integration of multiple measurement modalities.