Author

H. Hochegger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. K. Eykelenboom· 2 shared N. Hegarat· 2 shared T. U. Tanaka· 2 shared Z. Yue· 2 shared A. Crncec· 1 shared A. I. Lamond· 1 shared A. J. Booth· 1 shared A. R. Barr· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

J. K. Eykelenboom

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4 papers

Recent·Most cited

Genetic instability from a single S-phase after whole genome duplication

S. Gemble, R. Wardenaar, K. Keuper, N. Srivastava, M. Nano, A.-S. Mace, A. Tijhuis, S. V. Bernhard, D. C. J. Spierings, A. Simon, O. Goundiam, H. Hochegger, M. Piel, F. Foijer, Z. Storchova, R. Basto

This study shows that newly formed tetraploid human cells experience high DNA damage during the first S-phase, leading to abnormal karyotypes and genetic instability.

bioRxiv · Jul 16, 2021Cell Biology

Cyclin A triggers Mitosis either via Greatwall or Cyclin B

N. Hegarat, A. Crncec, M. F. Suarez Peredo Rodriguez, F. Echegaray Iturra, Y. Gu, P. F. Lang, A. R. Barr, C. Bakal, M. T. Kanemaki, A. I. Lamond, B. Novak, T. Ly, H. Hochegger

This study shows Cyclin A can trigger mitosis through Greatwall or Cyclin B by regulating Cdk1 activity and phosphorylation of mitotic substrates.

The EMBO Journal · Apr 30, 2020Peer-reviewedCell Biology

Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis

A. J. Booth, Z. Yue, J. K. Eykelenboom, T. Stiff, G. G. Luxton, H. Hochegger, T. U. Tanaka

The paper quantifies chromosome-scattering volume and shows that an acto-myosin network on nuclear envelope remnants reduces it, facilitating chromosome capture by spindle microtubules during mitosis.

bioRxiv · Mar 15, 2019Cell Biology

Live-cell imaging of marked chromosome regions reveals dynamics of mitotic chromosome resolution and compaction

J. K. Eykelenboom, M. Gierlinski, Z. Yue, N. Hegarat, H. Pollard, T. Fukagawa, H. Hochegger, T. U. Tanaka

The paper uses live-cell imaging to study mitotic chromosome resolution and compaction dynamics, revealing their timing and regulation.

bioRxiv · May 17, 2018Cell Biology