A. M. Sidebottom

Eubacterium rectale detoxification mechanism increases resilience of the gut environment

This study identifies Eubacterium rectale's detoxification mechanism, showing its ability to reduce ROS and inflammation in gut cells through glutathione production.

Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain

This paper shows that an avirulent C. difficile strain, ST1-75, protects mice from virulent strain-induced colitis by outcompeting it through rapid amino acid depletion, suggesting potential as a biotherapeutic for CDI prevention.

The Host-specific Microbiota is Required for Diet-Specific Metabolic Homeostasis

This study shows that host-specific microbiota are essential for maintaining diet-specific metabolic homeostasis, while foreign microbiota impair metabolic fitness in germ-free mice.

Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration

The paper identifies gut bacteria that use dietary and host-derived metabolites as electron acceptors in anaerobic respiration, revealing new metabolic pathways and reductase evolution.

Distinct energy-coupling factor transporter subunits enable flavin acquisition and extracytosolic trafficking for extracellular electron transfer in Listeria monocytogenes

This study identifies ECF transporter subunits involved in flavin export for flavinylation in L. monocytogenes and shows their directional transport and genomic distribution.

Dynamic genetic adaptation of Bacteroides thetaiotaomicron murine gut colonization

This study tracks genetic and metabolic changes in Bacteroides thetaiotaomicron during gut colonization, showing shifting gene usage and highlighting the importance of carbohydrate metabolism for long-term persistence.