Author

S. L. Gelhaus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

K. M. Aird· 2 shared N. Hempel· 2 shared S. J. Mullett· 2 shared A. Amalric· 1 shared A. E. Abdelnaby· 1 shared A. Koudelka· 1 shared A. N. Grumet· 1 shared A. R. Cole· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

K. M. Aird

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling

A. Koudelka, G. J. Buchan, V. Cechova, J. P. O`Brien, H. Liu, S. R. Woodcock, S. J. Mullett, C. Zhang, B. A. Freeman, S. L. Gelhaus

This paper shows that LXA4 and its 15-oxo metabolite do not activate FPR2 receptor but instead modulate redox-sensitive pathways through electrophilic interactions.

bioRxiv · Feb 6, 2024 · PreprintBiochemistry

ATR promotes mTORC1 activity via de novo cholesterol synthesis

N. K. Tangudu, A. N. Grumet, R. Fang, R. Buj, A. R. Cole, A. Uboveja, A. Amalric, B. Yang, Z. Huang, C. Happe, M. Sun, S. L. Gelhaus, M. L. MacDonald, N. Hempel, N. W. Snyder, , K. M. Aird

This study shows ATR enhances mTORC1 activity through cholesterol synthesis via LSS, independent of CHK1 and TSC, and this effect is amplified in p16-deficient cells.

bioRxiv · Oct 27, 2023Cell Biology

Alternative splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer.

Z. Javed, D. H. Shin, W. Pan, S. R. White, Y. S. Kim, A. T. Elhaw, S. Kamlapurkar, Y.-Y. Cheng, J. C. Benson, A. E. Abdelnaby, R. Phaeton, H.-G. Wang, S. Yang, M. L. G. Sullivan, C. St. Croix, , N. Hempel

This study identifies an alternative splice variant of Drp1 in ovarian cancer that promotes metastasis and chemoresistance by altering mitochondrial dynamics.

bioRxiv · Sep 20, 2023Cancer Biology