MYC/MIZ1 suppression of lysosomal protein degradation drives immune evasion in pancreatic ductal adenocarcinoma
Bastian Krenz, Toshitha Kannan, Greta Mattavelli, Werner Schmitz, Anneli Gebhardt-Wolf, Mara John, Ana Cetkovic, Arpa Aintablian, Stella Caviccioli, Lukas Nowak, Sarah Bopp, Christina Schuelein‐Voelk, Carsten Patrick Ade, Steffi Herold, Julian Bender, , Martin Eilers
This study shows that MYC suppresses lysosomal protein degradation in pancreatic ductal adenocarcinoma, promoting immune evasion by altering amino acid availability and immune cell responses.
bioRxiv · Jul 23, 2026 · PreprintCancer Biology