Remodeling oligodendrocyte lipid metabolism via liver X receptors overcomes inflammatory blockade of remyelination
Judy J. Lee, Matthew D. Smith, Xiaojing Deng, Jingwen Hu, Andrew Love, Jerry S Jing, Payam Mohammad Gharibani, Pragney Deme, Abdulshakour Mohammadnia, Qiao‐Ling Cui, Daryan Chitsaz, Asmita Dhukhwa, Jaime Gonzalez Cardona, Kathryn C. Fitzgerald, Colleen T. Harrington, , Michael D. Kornberg
This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.
bioRxiv · Aug 15, 2026 · PreprintNeuroscience