IL-12 Secreting CAR-T Cells Reprogram the Tumor Microenvironment and Improve Efficacy Against Heterogeneous Models of Glioblastoma
Steven Shen, Aditya A Mohan, Kelly M. Hotchkiss, Sarah L. Cook, Kisha Patel, Eliese Moelker, Bhairavy J. Puviindran, Ariel T Gonzalez, Saïf Eddine Zaidi, Samantha E. Spellicy, Adam Schwartz, Carter M. Suryadevara, Daniel Wilkinson, Katayoun Ayasoufi, Peter Edward Fecci, , Anoop P. Patel
This study shows that IL-12-secreting CAR-T cells improve glioblastoma treatment by enhancing T-cell persistence and reprogramming the tumor microenvironment without lymphodepletion.
Journal for ImmunoTherapy of Cancer · Mar 1, 2026Peer-reviewedImmunology