Author

Steven Shen

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Adam SchwartziD· 1 shared Aditya A MohaniD· 1 shared Anoop P. PateliD· 1 shared Ariel T Gonzalez· 1 shared Bhairavy J. PuviindraniD· 1 shared Carter M. SuryadevaraiD· 1 shared Chongzhi ZangiD· 1 shared Chunyuan JiniD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Adam SchwartzORCID

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2 papers

Recent·Most cited

IL-12 Secreting CAR-T Cells Reprogram the Tumor Microenvironment and Improve Efficacy Against Heterogeneous Models of Glioblastoma

Steven Shen, Aditya A Mohan, Kelly M. Hotchkiss, Sarah L. Cook, Kisha Patel, Eliese Moelker, Bhairavy J. Puviindran, Ariel T Gonzalez, Saïf Eddine Zaidi, Samantha E. Spellicy, Adam Schwartz, Carter M. Suryadevara, Daniel Wilkinson, Katayoun Ayasoufi, Peter Edward Fecci, , Anoop P. Patel

This study shows that IL-12-secreting CAR-T cells improve glioblastoma treatment by enhancing T-cell persistence and reprogramming the tumor microenvironment without lymphodepletion.

Journal for ImmunoTherapy of Cancer · Mar 1, 2026Peer-reviewedImmunology

Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements

Danqi Chen, Qiao Yi Chen, Zhenjia Wang, Yusha Zhu, Thomas Kluz, Wuwei Tan, Jinquan Li, Feng Chi Wu, Lei Fang, Xiaoru Zhang, Rong‐Quan He, Steven Shen, Hong Sun, Chongzhi Zang, Chunyuan Jin, Max Costa

The paper shows that polyadenylation of H3.1 mRNA displaces H3.3 from gene regulatory elements, leading to cell transformation and genomic instability.

iScience · Jan 1, 2019Peer-reviewedMolecular Biology