Author

John Howard Sampson

Duke UniversityORCID 0000-0002-0104-7658Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:multiome· 1 Assay:proteomics· 1

Frequent Co-Authors

Bhairavy J. PuviindraniD· 2 shared Eliese MoelkeriD· 2 shared Katayoun AyasoufiiD· 2 shared Kelly M. HotchkissiD· 2 shared Peter Edward FecciiD· 2 shared Sarah L. CookiD· 2 shared Adam SchwartziD· 1 shared Aditya A MohaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Bhairavy J. PuviindranORCID

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2 papers

Recent·Most cited

IL-12 Secreting CAR-T Cells Reprogram the Tumor Microenvironment and Improve Efficacy Against Heterogeneous Models of Glioblastoma

Steven Shen, Aditya A Mohan, Kelly M. Hotchkiss, Sarah L. Cook, Kisha Patel, Eliese Moelker, Bhairavy J. Puviindran, Ariel T Gonzalez, Saïf Eddine Zaidi, Samantha E. Spellicy, Adam Schwartz, Carter M. Suryadevara, Daniel Wilkinson, Katayoun Ayasoufi, Peter Edward Fecci, , Anoop P. Patel

This study shows that IL-12-secreting CAR-T cells improve glioblastoma treatment by enhancing T-cell persistence and reprogramming the tumor microenvironment without lymphodepletion.

Journal for ImmunoTherapy of Cancer · Mar 1, 2026Peer-reviewedImmunology

IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models

Kirit Singh, Kelly M. Hotchkiss, Sarah L. Cook, Pamy Noldner, Ying Zhou, Eliese Moelker, Chelsea O. Railton, Emily E. Blandford, Bhairavy J. Puviindran, Shannon E. Wallace, Pamela K. Norberg, Gary E. Archer, Beth H. Shaz, Katayoun Ayasoufi, John Howard Sampson, , Peter Edward Fecci

This study shows that IL-7-expanded autologous lymphocytes increase VLA-4 expression and accumulate in glioblastoma tumors, enhancing the effectiveness of T cell-based therapies.

Journal of Clinical Investigation · Apr 17, 2025Peer-reviewedCancer Biology