Author

Peter Edward Fecci

Duke Medical CenterORCID 0000-0002-2912-8695Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Katayoun AyasoufiiD· 3 shared Kelly M. HotchkissiD· 3 shared Sarah L. CookiD· 3 shared Aditya A MohaniD· 2 shared Anoop P. PateliD· 2 shared Bhairavy J. PuviindraniD· 2 shared Eliese MoelkeriD· 2 shared Emily E. BlandfordiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

Katayoun AyasoufiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ImmunologyJournal for ImmunoTherapy of CancerPeer-reviewedMar 1, 2026

IL-12 Secreting CAR-T Cells Reprogram the Tumor Microenvironment and Improve Efficacy Against Heterogeneous Models of Glioblastoma

Steven Shen, Aditya A Mohan, Kelly M. Hotchkiss…·Anoop P. Patel

This study shows that IL-12-secreting CAR-T cells improve glioblastoma treatment by enhancing T-cell persistence and reprogramming the tumor microenvironment without lymphodepletion.

4 citationstop 2%

mouseexperimental assay

𝕏 PostBluesky

ImmunologyClinical Cancer ResearchPeer-reviewedNov 21, 2025

Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity

Alexandra M. Hoyt-Miggelbrink, Jessica Waibl Polania, Lucas P. Wachsmuth…·Peter Edward Fecci

6 citations

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologyJournal of Clinical InvestigationPeer-reviewedApr 17, 2025

IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models

Kirit Singh, Kelly M. Hotchkiss, Sarah L. Cook…·Peter Edward Fecci

This study shows that IL-7-expanded autologous lymphocytes increase VLA-4 expression and accumulate in glioblastoma tumors, enhancing the effectiveness of T cell-based therapies.

9 citations

mousehuman

𝕏 PostBluesky