Author

B. E. Krumm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Organism:human· 1

Frequent Co-Authors

B. L. Roth· 2 shared A. B. Pinkerton· 1 shared C. Mao· 1 shared H. E. Xu· 1 shared H. J. Kang· 1 shared H. Li· 1 shared J. F. DiBerto· 1 shared L. M. Slosky· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

B. L. Roth

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2 papers

Recent·Most cited

Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator

B. E. Krumm, J. F. DiBerto, R. H. J. Olsen, H. J. Kang, S. T. Slocum, S. Zhang, R. T. Strachan, L. M. Slosky, A. B. Pinkerton, L. S. Barak, M. G. Caron, T. Kenakin, B. L. Roth

This study reveals the cryoEM structures of NTSR1 with and without SBI-553, showing its biased allosteric modulation of G protein and β-Arrestin signaling.

bioRxiv · Dec 26, 2022 · PreprintBiophysics

Structural Genomics of the Human Dopamine Receptor System

P. Xu, S. Huang, B. E. Krumm, Y. Zhuang, C. Mao, Y. Zhang, Y. Wang, X.-P. Huang, Y.-F. Liu, X. He, H. Li, W. Yin, Y. Jiang, Y. Zhang, B. L. Roth, H. E. Xu

This study reports cryo-EM structures of all human dopamine receptor subtypes bound to Rotigotine, revealing binding modes, activation mechanisms, and G-protein coupling specificity for drug design.

bioRxiv · Oct 9, 2022Biochemistry