B. H. Lee

Heat shock induces alternative polyadenylation through dynamic DNA methylation-regulated chromatin looping

The paper shows heat shock induces alternative polyadenylation by dynamically regulating DNA methylation and chromatin looping at the DNAJB6 gene.

Time-resolved analysis of transcription kinetics in single live mammalian cells

The paper develops a method to measure transcription kinetics in live cells using time-lapse imaging and mathematical modeling, finding elongation rates and termination times for specific mRNAs.

Perturb-map enables CRISPR genomics with spatial resolution and identifies regulators of tumor immune composition

Perturb-map enables spatial CRISPR screening in tumors, identifying genes that regulate immune composition by mapping gene knockouts and their effects on the tumor microenvironment.

Members of the ELMOD protein family specify formation of distinct aperture domains on the Arabidopsis pollen surface

The paper identifies ELMOD proteins in Arabidopsis that control aperture domain formation on pollen surfaces, showing their roles in regulating aperture number, position, and morphology.

miRNA-34c suppresses osteosarcoma progression in vivo by targeting Notch and E2F

This study shows miR-34c suppresses osteosarcoma progression by targeting Notch and E2F pathways, improving survival in mouse models and correlating with better patient outcomes.

An unorthodox mechanism underlying voltage sensitivity of TRPV1 ion channel

This study identifies an unconventional voltage-sensing mechanism in TRPV1 channels where outer pore acidic residues, not the S4 segment, mediate voltage sensitivity and activation.

A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer

The paper describes a modified Helios mass cytometer protocol that improves data quality and reduces inter-instrument variability in multi-center studies.