Author

B. D. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Baccarini· 3 shared G. Mollaoglu· 2 shared L. Pia· 2 shared M. Dhainaut· 2 shared M. Merad· 2 shared S. R. Nielsen· 2 shared A. Bektesevic· 1 shared A. H. Rahman· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

A. Baccarini

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling

V. Q.-H. Trinh, T.-F. Lee, S. Lemoinne, K. C. Ray, M. D. Ybanez, T. Tsuchida, J. K. Carter, J. Agudo, B. D. Brown, K. M. Akat, S. L. Friedman, Y. A. Lee

This study shows hepatic stellate cells promote midlobular hepatocyte proliferation and metabolic zonation by secreting neurotrophin-3.

bioRxiv · Mar 3, 2023 · PreprintCell Biology

Targeting macrophages with CAR-T cells delays solid tumor progression and enhances anti-tumor immunity

A. R. Sanchez-Paulete, J. Mateus-Tique, G. Mollaoglu, S. R. Nielsen, A. Marks, A. Lakshmi, L. Pia, A. Baccarini, M. Merad, B. D. Brown

This study shows that CAR-T cells targeting macrophages delay tumor growth and improve survival in mouse models of solid tumors by enhancing anti-tumor immunity.

bioRxiv · Dec 17, 2021Immunology

Perturb-map enables CRISPR genomics with spatial resolution and identifies regulators of tumor immune composition

M. Dhainaut, S. A. Rose, G. Akturk, A. Wroblewska, E. Sook Park, S. R. Nielsen, M. Buckup, V. Roudko, L. Pia, J. Le Berichel, A. Bektesevic, B. H. Lee, A. Baccarini, N. Bhardwaj, A. H. Rahman, , B. D. Brown

Perturb-map enables spatial CRISPR screening in tumors, identifying genes that regulate immune composition by mapping gene knockouts and their effects on the tumor microenvironment.

bioRxiv · Jul 13, 2021 · PreprintImmunology

P53 is a direct regulator of the immune co-stimulatory molecule CD80

E. Alibo, G. Mollaoglu, M. Dhainaut, R. Zhao, S. Rose, A. Baccarini, R. Parsons, B. D. Brown

This study identifies CD80 as a direct target of P53, showing that P53 loss reduces CD80 expression and impairs T cell priming in colorectal cancer.

bioRxiv · May 24, 2021 · PreprintImmunology