Author

B. J. Polacco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

N. J. Krogan· 4 shared A. Garcia-Sastre· 2 shared D. L. Swaney· 2 shared L. Zuliani-Alvarez· 2 shared M. Soucheray· 2 shared R. M. Kaake· 2 shared A. Cupic· 1 shared A. Gaba· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

N. J. Krogan

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Protein interaction map of APOBEC3 enzyme family reveals deamination-independent role in cellular function

G. M. Jang, A. K. A. Sudarsan, A. Shayeganmehr, E. P. Munhoz, R. Lao, A. Gaba, M. G. Rodriguez, R. P. Love, B. J. Polacco, Y. Zhou, N. J. Krogan, R. M. Kaake, L. Chelico

The paper identifies novel protein and RNA interactions of APOBEC3 enzymes, revealing deamination-independent roles in RNA biology and cancer.

bioRxiv · Feb 6, 2024Biochemistry

Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.

T. Kehrer, A. Cupic, C. Ye, S. Yildiz, M. Bouhhadou, N. A. Crossland, E. Barrall, P. Cohen, A. Tseng, T. Cagatay, R. Rathnasinghe, D. Flores, S. Jangra, F. Alam, N. Mena, , L. Miorin

This study shows SARS-CoV-2 ORF6 disrupts nucleo-cytoplasmic trafficking, inhibits IFN signaling, and modulates viral protein expression, with variant polymorphisms affecting its function.

bioRxiv · Oct 18, 2022Microbiology

De novo protein identification in mammalian sperm using high-resolution in situ cryo-electron tomography

Z. Chen, M. Shiozaki, K. M. Haas, S. Zhao, C. Guo, B. J. Polacco, Z. Yu, N. J. Krogan, R. M. Kaake, R. D. Vale, D. A. Agard

The paper identifies novel sperm proteins in mammals using cryo-electron tomography and AlphaFold2 models, revealing their structural roles in flagellar mechanics.

bioRxiv · Sep 28, 2022Biophysics

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

L. G. Thorne, M. Bouhaddou, A.-K. Reuschl, L. Zuliani-Alvarez, B. J. Polacco, A. Pelin, J. Batra, M. V. X. Whelan, M. Ummadi, A. Roic, J. Turner, K. Obernier, H. Braberg, M. Soucheray, A. L. Richards, , N. J. Krogan

This study identifies that the B.1.1.7 SARS-CoV-2 variant enhances innate immune evasion through increased Orf9b and Orf6 expression and activity.

bioRxiv · Jun 6, 2021 · PreprintMicrobiology