G. M. Jang

Protein interaction map of APOBEC3 enzyme family reveals deamination-independent role in cellular function

The paper identifies novel protein and RNA interactions of APOBEC3 enzymes, revealing deamination-independent roles in RNA biology and cancer.

Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophila

This study identifies how Legionella pneumophila modifies host ubiquitination during infection, revealing widespread monoubiquitination of small GTPases and the role of SidC/SdcA effectors.

HBV rewires liver cancer signaling by altering PP2A complexes

This study identifies how HBV alters PP2A complexes to drive liver cancer signaling, revealing potential therapeutic targets.

Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3

The paper reports the cryo-EM structure of SETD3 interacting with enterovirus protease 2A and shows that mutations in the SET domain reduce binding and protect against infection.

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

A tyrosine kinase protein interaction map reveals targetable EGFR network oncogenesis in lung cancer

The paper constructs a tyrosine kinase protein interaction map, revealing EGFR network oncogenesis in 19% of EGFR wild-type lung cancers, which is targetable with EGFR inhibitors.

Dynamic proteomics profiling of Legionella pneumophila infection unveils modulation of the host mitochondrial stress response pathway

This study profiles host cell proteome, ubiquitinome, and phosphoproteome during Legionella pneumophila infection, revealing modulation of mitochondrial stress response pathways.