T. Jacob

SARS-CoV-2 Omicron Envelope T9I adaptation confers resistance to autophagy

The paper shows that the T9I mutation in the SARS-CoV-2 E protein confers autophagy resistance in Omicron variants, contributing to their spread.

Cancer associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy

This study identifies three CAF subtypes in skin cancers and shows their association with tumor malignancy and immune modulation.

Determinants of Spike Infectivity, Processing and Neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

This study examines how specific mutations in the SARS-CoV-2 Omicron Spike protein affect infectivity, processing, and neutralization by antibodies.

An increase in surface hydrophobicity mediates chaperone activity in N-chlorinated proteins

This study identifies specific chlorinated residues in RidA that are critical for its chaperone activity under oxidative stress.

Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2

The paper shows that a single amino acid mutation in the Spike protein of bat coronavirus RaTG13 enables it to use human ACE2 for infection.

Natural Cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling

The paper identifies a Cystatin C fragment that inhibits GPR15-mediated HIV and SIV infection without affecting GPR15L signaling.

The molecular anatomy of mouse skin during hair growth and rest

The paper creates a comprehensive single-cell transcriptome atlas of mouse skin during hair growth and rest, identifying key cell populations and their molecular and spatial organization.

HER2 Cancer Protrusion Growth Signaling Regulated by Unhindered, Localized Filopodial Dynamics

This study investigates how HER2 dynamics in filopodia regulate protrusion growth and signaling in breast cancer cells, revealing distinct motion patterns and functional roles in protrusion-based signaling.