Author

X. Nan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:fluorescence / live-cell microscopy· 2 Approach:microscopy & imaging analysis· 2 Assay:protein sequence· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Y. Zhang· 4 shared Y. H. Chang· 3 shared B. Mostofian· 2 shared D. M. Zuckerman· 2 shared J. W. Gray· 2 shared K. Chin· 2 shared Y. Wang· 2 shared A. Agrawal· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersBiophysics

Y. Zhang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

De novo multi-mechanism antimicrobial peptide design via multimodal deep learning

Y. Wang, H. Gong, X. Li, L. Li, Y. Zhao, P. Bao, Q. Kong, B. Wan, Y. Zhang, J. Zhang, J. Ni, Z. Han, X. Nan, K. Ju, L. Sun, , Y. Li

This paper introduces M3-CAD, a deep learning pipeline for designing multi-mechanism antimicrobial peptides to combat multidrug-resistant organisms, showing effectiveness in a skin wound infection model.

bioRxiv · Jan 2, 2024 · PreprintBioengineering

Multiplexed and millimeter-scale fluorescence nanoscopy of cells and tissue sections via prism-illumination and microfluidics-enhanced DNA-PAINT

M. J. Rames, J. Kenison, D. Heineck, F. Civitci, M. Szczepaniak, T. Zheng, J. Shangguan, Y. Zhang, S. Esener, X. Nan

This paper introduces PRIME-PAINT, a method for multiplexed fluorescence nanoscopy with millimeter-scale field-of-view and high resolution, demonstrating its use on biological samples.

bioRxiv · Aug 7, 2022 · PreprintBiophysics

An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer

B. E. Johnson, A. L. Creason, J. M. Stommel, J. M. Keck, S. Parmar, C. B. Betts, A. Blucher, C. Boniface, E. Bucher, E. A. Burlingame, T. Camp, K. Chin, J. Eng, J. Estabrook, H. S. Feiler, , J. W. Gray

This paper presents an OMS Atlas from serial biopsies of a metastatic breast cancer patient, linking clinical data to multi-omic and spatial profiles to study therapy-associated heterogeneity and resistance mechanisms.

bioRxiv · Dec 3, 2020Cancer Biology

Crosstalk between invadopodia and the extracellular matrix

S. Iizuka, R. P. Leon, K. P. Gribbin, Y. Zhang, J. Navarro, R. Smith, K. Devlin, L. G. Wang, S. L. Gibbs, J. Korkola, X. Nan, S. A. Courtneidge

This study investigates the interaction between invadopodia and the extracellular matrix, showing that Tks5 is involved in matrix-dependent growth and invadopodia formation.

bioRxiv · Feb 26, 2020Cancer Biology

HER2 Cancer Protrusion Growth Signaling Regulated by Unhindered, Localized Filopodial Dynamics

W. Y. Lam, Y. Wang, B. Mostofian, D. Jorgens, S. Kwon, K. Chin, M. Carpenter, T. Jacob, K. Heiser, A. Agrawal, J. Wang, X. Nan, Y. H. Chang, D. M. Zuckerman, J. Gray, , T. Q. Vu

This study investigates how HER2 dynamics in filopodia regulate protrusion growth and signaling in breast cancer cells, revealing distinct motion patterns and functional roles in protrusion-based signaling.

bioRxiv · Jun 2, 2019 · PreprintCancer Biology

High-throughput single-particle tracking reveals nested membrane nanodomain organization that dictates Ras diffusion and trafficking

Y. Lee, C. Phelps, T. Huang, B. Mostofian, L. Wu, Y. Zhang, Y. H. Chang, P. J. S. Stork, J. W. Gray, D. M. Zuckerman, X. Nan

This study uses single-particle tracking to show that KRas diffusion and trafficking are regulated by nested membrane nanodomains in U2OS cells.

bioRxiv · Mar 5, 2019Biophysics