Author

J. W. McCauley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:plant (other)· 2 Organism:virus· 2 Approach:Bayesian inference· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

R. S. Daniels· 4 shared A. McNee· 2 shared A. R. Townsend· 2 shared B. Paudyal· 2 shared E. Tchilian· 2 shared L. Whittaker· 2 shared P. Rijal· 2 shared A. J. Hay· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersImmunology

R. S. Daniels

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A Bayesian approach to incorporate structural data into the mapping of genotype to antigenic phenotype of influenza A(H3N2) viruses

W. T. Harvey, V. Davies, R. S. Daniels, L. Whittaker, V. Gregory, A. J. Hay, D. Husmeier, J. W. McCauley, R. Reeve

This paper uses a Bayesian model to identify genetic changes in influenza A(H3N2) viruses that drive antigenic drift by incorporating protein structural data to improve variable selection accuracy.

bioRxiv · Mar 26, 2022Microbiology

Low dose pig anti-influenza virus monoclonal antibodies reduce lung pathology but do not prevent virus shedding

B. Paudyal, A. McNee, P. Rijal, B. V. Carr, A. Nunez, J. W. McCauley, R. S. Daniels, A. R. Townsend, J. A. Hammond, E. Tchilian

This study shows that high-dose pig monoclonal antibodies reduce lung pathology and virus load but not nasal shedding, suggesting lower doses may suffice for disease severity reduction.

bioRxiv · Oct 8, 2021Immunology

Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

B. Holzer, P. Rijal, A. McNee, B. Paudyal, B. Clark, T. Manjegowda, F. J. Salguero, E. Bessell, J. C. Schwartz, K. Moffat, M. Pedrera, S. P. Graham, M. B.-D. Placido, R. M. La Ragione, W. Mwangi, , E. Tchilian

This study generates pig-specific monoclonal antibodies against H1N1pdm09 influenza virus that target human-like HA epitopes and reduce disease severity in pigs.

bioRxiv · Jul 21, 2020Immunology

Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

J. Huddleston, J. R. Barnes, T. Rowe, R. Kondor, D. E. Wentworth, L. Whittaker, B. Ermetal, R. S. Daniels, J. W. McCauley, S. Fujisaki, K. Nakamura, N. Kishida, S. Watanabe, H. Hasegawa, I. Barr, , T. Bedford

This study develops a forecasting framework for influenza A/H3N2 evolution by integrating phenotypic antigenic drift data with sequence-based fitness estimates, showing improved long-term predictions.

bioRxiv · Jun 12, 2020Evolutionary Biology

Segment 2 from influenza A(H1N1)pdm09 viruses confers temperature sensitive HA yield on candidate vaccine virus growth in eggs that is complemented by PB2 701D

S. Hussain, M. L. Turnbull, R. M. Pinto, J. W. McCauley, O. G. Engelhardt, P. Digard

This study shows that pdm09 segment 2 in candidate vaccine viruses reduces HA yield in eggs at 37.5°C but this temperature sensitivity is compensated by the PB2 701D mutation, improving HA yield.

bioRxiv · Feb 8, 2019Microbiology