P. Zheng

Molecular Evidence of Internal Carbon-Driven Partial Denitrification Annamox (PdNA) in a mainstream Pilot A-B System Coupled with Side-stream EBPR treating municipal wastewater

This study demonstrates that a pilot-scale A-B-S2EBPR system achieves nitrite accumulation and anammox for nitrogen removal in wastewater treatment by utilizing internal carbon sources.

Cell-type-specific 3D-genome organization and transcription regulation in the brain

The paper investigates 3D-genome organization and transcription regulation in distinct cell types of the mouse brain, finding cell-type-specific nuclear architecture and chromatin compartmentalization correlated with transcriptional activity and MeCP2 regulation.

Substrate specificity and functional conservation of SWEET10 transporter in pineapple

This study examines the substrate specificity and functional conservation of the SWEET10 transporter in pineapple by comparing it to Arabidopsis SWEET8 and analyzing its role in microspore formation.

Cooperative Motility, Force Generation and Mechanosensing in a Foraging Non-Photosynthetic Diatom

This study characterizes non-photosynthetic diatoms, revealing glucose-mediated catabolite repression, EPS deposition, and cooperative motility mechanisms linked to heterotrophy.

CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment

The paper shows that anti-CTLA-4 ADC treatment causes B cell depletion via T cell hyper-proliferation and regulatory T cell impairment in CTLA-4 knock-in mice.

CARD8 negatively regulates NLRP1 inflammasome activation level by interaction with NLRP1

This study shows that the T60 variant of CARD8 inhibits NLRP1 inflammasome activation by interacting with NLRP1 and preventing inflammasome assembly.

S373P Mutation Stabilizes the Receptor-binding Domain of Spike Protein in Omicron and Promotes Binding

The paper investigates the effect of the S373P mutation on the stability and binding ability of the Omicron spike protein's RBD using AFM-SMFS and molecular dynamics simulations.

Lnc956-TRIM28-HSP90B1 complex on replication forks promotes CMG helicase retention to ensure stem cell genomic stability and embryogenesis

The paper identifies Lnc956 as a non-coding RNA that forms a complex with TRIM28 and HSP90B1 to prevent replication fork collapse and maintain genomic stability in mouse embryonic stem cells.

Hetero-bivalent Nanobodies Provide Broad-spectrum Protection against SARS-CoV-2 Variants of Concern including Omicron

This paper develops hetero-bivalent nanobodies that neutralize multiple SARS-CoV-2 variants, including Omicron, and show protective effects in vivo.

The infiltration pattern of microenvironmental cells and different immune escape mechanisms in colorectal cancer

The paper identifies three TME cell subtypes in colorectal cancer and their associated immune escape mechanisms using transcriptomic data from public datasets.

DNA Self-Assembled Plasmonic Nanodiamonds for Biological Sensing

This study develops plasmon-enhanced nanodiamonds (PEN) for biological imaging by using DNA self-assembly to improve brightness and temporal resolution of NV centers.

Mutation N501Y in RBD of Spike Protein Strengthens the Interaction between COVID-19 and its Receptor ACE2

This study investigates how the N501Y mutation in the SARS-CoV-2 spike protein's RBD enhances its binding to ACE2, contributing to increased transmissibility of variants.

Systematic analysis of the R2R3-MYB family of transcription factors in Camellia sinensis: evidence for species-specific catechin biosynthesis regulation

This study identifies R2R3-MYB transcription factors in C. sinensis and links some to the regulation of galloylated catechin biosynthesis.

Previously unrecognized non-reproducible antibody-antigen interactions and their implications for diagnosis of viral infections including COVID-19

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

Combined Enhanced Biological Phosphorus Removal (EBPR) and Nitrite Accumulation for Treating High-strength Wastewater

This study combines enhanced biological phosphorus removal with nitrite accumulation in a reactor treating synthetic digested manure wastewater, achieving high phosphorus removal and stable nitrite levels.

For running or burying -- The toe fringe of Phrynocephalus mystaceus is important

This study removes toe fringes from Phrynocephalus mystaceus to test their impact on locomotor and sand-diving performance, finding that toe fringe area significantly affects both.

A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer

The paper identifies CLN6 and the EGRESS complex as essential for lysosomal enzyme trafficking from the ER to the Golgi, revealing their role in Batten disease pathogenesis.