B. Wiedenheft

Viral proteins activate PARIS-mediated tRNA degradation and viral tRNAs rescue infection

The paper shows that viral proteins activate PARIS-mediated tRNA degradation, and viral tRNAs rescue infection by preventing cleavage.

Protein-mediated genome folding allosterically enhances site-specific integration of foreign DNA into CRISPRs

The paper determines the structure of a CRISPR integration complex and explains how it facilitates site-specific DNA integration through DNA bending and loop formation.

Bacterial threat assessment of bacteriophage infection is mediated by intracellular polyamine accumulation and Gac/Rsm signaling

This study shows that Pseudomonas aeruginosa uses intracellular polyamine accumulation and Gac/Rsm signaling to assess bacterial cell death and inhibit phage replication.

The rise and fall of SARS-CoV-2 variants and the emergence of competing Omicron lineages

The paper analyzes SARS-CoV-2 genome data to show Omicron variants have more non-synonymous mutations, especially in spike and nucleoproteins, compared to previous variants.

The rise and fall of SARS-CoV-2 variants and the mutational profile of Omicron

The paper analyzes SARS-CoV-2 genome data to show Omicron has higher mutation rates, primarily in the spike protein, and suggests implications for vaccines and public health strategies.

Bacteriophage cooperation suppresses CRISPR-Cas3 and Cas9 immunity

The paper shows that phages cooperate by sharing anti-CRISPR proteins to suppress bacterial CRISPR-Cas immunity, enabling successful infection when individual phages fail to replicate.