Author

J. Jellusova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

H. Jumaa· 2 shared M. M. Taketo· 2 shared A. Zach· 1 shared B. Suess· 1 shared B. Wollscheid· 1 shared C. Boehler· 1 shared C. Setz· 1 shared D. Fonseca-Arce· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

H. Jumaa

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies

K. N. Cosgun, H. Jumaa, M. E. Robinson, X. Liang, G. Xiao, L. N. Chan, J. Lee, K. Kume, E. Leveille, D. Fonseca-Arce, D. Khanduja, H. L. Ng, N. Feldhahn, J. Song, W. C. Chan, , M. Mueschen

This study identifies a unique vulnerability in B-cell malignancies where GSK3β inhibitors disrupt β-catenin-Ikaros complexes, leading to MYC repression and cell death.

bioRxiv · Mar 13, 2023 · PreprintCancer Biology

B cells are addicted to immunoglobulin production in the ER

M. Caganova, H. Taskiran, Y. Zong, A. Zach, E. Kabrani, K. Schmidt, P. Goffing, J. Jellusova, K. Rajewsky

The paper shows that B cells rely on ER-resident immunoglobulin heavy chains for ER homeostasis and mitochondrial function, independent of BCR signaling.

bioRxiv · Mar 11, 2022 · PreprintImmunology

Accumulation of the GSK3 target protein β-catenin is lethal for B cell precursors and malignant B cells

H. Jumaa, K. M. Kistner, C. Setz, M. M. Taketo, H. Jumaa, J. Jellusova

This study shows that β-catenin accumulation caused by GSK3 inhibition leads to reduced survival in B cell precursors and malignant B cells.

bioRxiv · Sep 17, 2021 · PreprintImmunology

CD20 as a gatekeeper of the resting stage of human B cells

K. Klasener, J. Jellusova, G. Andrieux, U. Salzer, C. Boehler, S. N. Steiner, J. B. Albinus, M. F. Cavallari, B. Suess, M. Boerries, R. E. Voll, B. Wollscheid, M. Reth

This study shows CD20 maintains the resting state of human B cells by organizing surface receptors, and its disruption leads to B cell activation and plasma cell differentiation.

bioRxiv · Jul 31, 2020Immunology