M. Boerries

Species-specific LUBAC-mediated M1 ubiquitination regulates necroptosis by segregating the cellular distribution and fate of activated MLKL

The paper identifies LUBAC-mediated M1 ubiquitination as a species-specific checkpoint regulating necroptosis by controlling MLKL membrane accumulation in human cells and organoids.

Proteogenomic analysis reveals RNA as an important source for tumor-agnostic neoantigen identification correlating with T-cell infiltration

This study identifies RNA as a significant source of tumor-agnostic neoantigens, which correlate with T-cell infiltration in multiple cancer types.

PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

This study identifies PI3K/AKT pathway activation as a mechanism for MAPK/ERK pathway independency in melanoma, leading to treatment resistance and stem-like properties.

Breast cancer stem cell-derived tumors escape from γδ T cell immunosurveillance in vivo by modulating γδ T cell ligands

This study shows that breast cancer stem cells escape γδ T cell immunosurveillance by losing key ligands and antigens, and that this escape can be reversed with Zoledronate or IFN- treatment.

USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING

This study identifies USP22 as a regulator of STING and type III IFN signaling, showing its role in SARS-CoV-2 infection and antiviral defense in human intestinal epithelial cells.

Spatially confined sub-tumor microenvironments orchestrate pancreatic cancer pathobiology

This study identifies spatially confined sub-tumor microenvironments in PDAC that drive distinct tumor progression outcomes.

Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT

This study shows that TGFβ1 induces collective invasion in colorectal cancer through a Snail1- and Zeb1-independent partial EMT, resembling CMS4 cancers with poor prognosis.

CD20 as a gatekeeper of the resting stage of human B cells

This study shows CD20 maintains the resting state of human B cells by organizing surface receptors, and its disruption leads to B cell activation and plasma cell differentiation.

Lineage and Spatial Mapping of Glioblastoma-associated Immunity

This study maps immune cell states and interactions in glioblastoma, identifying IL-10-driven T cell exhaustion and myeloid-lymphoid interactions contributing to immunosuppression.

ZBTB18 inhibits SREBP-dependent fatty acid synthesis by counteracting CTBPs and KDM1A/LSD1 activity in glioblastoma

This study identifies ZBTB18 as a regulator of SREBP gene expression in glioblastoma by modulating CTBP and LSD1 activity, leading to epigenetic repression of fatty acid synthesis.

Image-derived Models of Cell Organization Changes During Differentiation of PC12 Cells

The paper develops a generative model to track cell organization changes during PC12 differentiation using static images and shape analysis.