W. C. Earnshaw

Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore

This study shows that kinetochore dynein can biorient chromosomes and remodel the outer kinetochore, but not congress them, during mitosis.

Condensin reorganizes centromeric chromatin during mitotic entry into a bipartite structure stabilized by cohesin

This study shows vertebrate centromeres form a bipartite structure during mitosis, stabilized by condensin and linked by cohesin, which prevents merotelic attachments and chromosomal instability.

Mapping the invisible chromatin transactions of prophase chromosome remodelling

The paper maps early chromatin transactions during mitotic entry in chicken cells using proteomics and imaging, revealing dynamic changes in chromatin associations and protein dynamics.

Direct Nucleosome Binding of Borealin Secures Chromosome Association and Function of the Chromosomal Passenger complex

This study identifies Borealin as the key mediator of Chromosomal Passenger Complex (CPC) chromosome association through direct nucleosome binding, revealing its critical role in chromosome segregation.

Rapid degradation and 3D CLEM of condensin reveal chromatin compaction uncoupled from chromosome architecture in mitosis

This study shows that condensin is essential for anaphase chromosome segregation and normal chromosome architecture formation, but not for chromatin compaction during mitosis.