Author

C. J. Weinheimer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 3 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Kovacs· 5 shared K. J. Lavine· 3 shared A. L. Koenig· 2 shared D. Kreisel· 2 shared F. F. Kadyrov· 2 shared J. M. Amrute· 2 shared J. M. Nigro· 2 shared A. Bredemeyer· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersImmunology

A. Kovacs

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5 papers

Recent·Most cited

Genetic Mapping of Monocyte Fate Decisions Following Myocardial Infarction

A. L. Koenig, F. F. Kadyrov, J. M. Amrute, S. Yang, C. J. Weinheimer, J. M. Nigro, A. Kovacs, G. Smith, K. J. Lavine

The paper maps monocyte differentiation trajectories in the infarcted heart using genetic lineage tracing and single-cell RNA-sequencing, identifying a protective IFN-responsive macrophage subset.

bioRxiv · Dec 24, 2023Immunology

Hypoxia Sensing in Resident Cardiac Macrophages Regulates Monocyte Fate Specification following Ischemic Heart Injury

F. F. Kadyrov, A. L. Koenig, J. M. Amrute, H. Dun, W. Li, C. J. Weinheimer, J. M. Nigro, A. Kovacs, A. L. Bredemeyer, L. Lai, B. J. Kopecky, V. Penna, D. Kreisel, K. J. Lavine

This study shows that hypoxia sensing in cardiac macrophages influences monocyte differentiation into inflammatory states after heart injury.

bioRxiv · Aug 4, 2022 · PreprintImmunology

Dapagliflozin improves endothelial integrity and hemodynamics in endotoxin treated mice through an apolipoprotein M dependent pathway

C. Valenzuela Ripoll, Z. Guo, T. Kumari, K. N. Miyata, M. Ozcan, A. Diab, A. Girardi, L. He, A. Kovacs, C. J. Weinheimer, J. Nigro, J. Oscarsson, R. Esterline, J. Schilling, M. Kosiborod, , A. Javaheri

This study shows dapagliflozin improves hemodynamics and endothelial integrity in endotoxin-treated mice via the ApoM/S1P pathway by preserving megalin expression.

bioRxiv · Apr 27, 2022 · PreprintPhysiology

Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling

N. R. Wong, J. Mohan, B. Kopecky, S. Guo, L. Du, J. Leid, O. Dmytrenko, H. Luehmann, G. Bajpai, L. Ewald, L. Bell, N. Patel, I. Lokshina, A. Bredemeyer, C. J. Weinheimer, , K. J. Lavine

This study identifies CCR2- resident cardiac macrophages as critical for adaptive myocardial remodeling in heart failure, showing their role in ventricular remodeling and coronary angiogenesis.

bioRxiv · Jan 28, 2021Immunology

Ketogenic Diet Prevents Heart Failure from Defective Mitochondrial Pyruvate Metabolism

K. S. McCommis, A. Kovacs, C. J. Weinheimer, T. M. Shew, T. R. Koves, O. R. Ilkayeva, D. R. Kamm, K. D. Pyles, M. T. King, R. L. Veech, B. J. DeBosch, D. M. Muoio, R. W. Gross, B. N. Finck

This study shows that a ketogenic diet prevents heart failure in mice with defective mitochondrial pyruvate metabolism by reversing cardiac remodeling and dysfunction.

bioRxiv · Feb 21, 2020Physiology