Author

I. Krystkowiak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

Y. Ivarsson· 4 shared L. Simonetti· 3 shared N. E. Davey· 3 shared A. Sayadi· 2 shared C. Benz· 2 shared E. Andersson· 2 shared F. Mihalic· 2 shared J. Kliche· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiochemistry

Y. Ivarsson

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Author profile →

4 papers

Recent·Most cited

Proteome-scale characterisation of motif-based interactome rewiring by disease mutations

J. Kliche, L. Simonetti, I. Krystkowiak, H. Kuss, M. Diallo, E. Rask, J. Nilsson, N. Davey, Y. Ivarsson

The paper characterizes how disease mutations in intrinsically disordered regions modulate protein interactions mediated by short linear motifs, identifying both loss and gain of interactions.

bioRxiv · Sep 18, 2023Biochemistry

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

F. Mihalic, L. Simonetti, G. Giudice, M. Rubin Sander, R. Lindqvist, M. B. A. Peters, C. Benz, E. Kassa, D. Badgujar, R. Inturi, M. Ali, I. Krystkowiak, A. Sayadi, E. Andersson, H. Aronsson, , Y. Ivarsson

The paper uses phage-based screening to identify 1,712 virus-host interactions mimicking host short linear motifs, revealing therapeutic targets for broad-spectrum antivirals.

bioRxiv · Jun 19, 2022 · PreprintBiochemistry

Proteome-scale amino-acid resolution footprinting of protein-binding sites in the intrinsically disordered regions of the human proteome

C. Benz, M. Ali, I. Krystkowiak, L. Simonetti, A. Sayadi, F. Mihalic, J. Kliche, E. Andersson, P. Jemth, N. E. Davey, Y. Ivarsson

The paper introduces HD2, a proteome-scale method for identifying and characterizing SLiM-mediated protein interactions with amino acid resolution, and provides tools for analyzing the results.

bioRxiv · Apr 13, 2021Biochemistry

Systematic discovery of Short Linear Motifs decodes calcineurin phosphatase signaling

C. P. Wigington, J. Roy, N. P. Damle, V. K. Yadav, C. Blikstad, E. Resch, C. J. Wong, D. R. Mackay, J. T. Wang, I. Krystkowiak, D. A. Bradburn, E. Tsekitsidou, S. H. Hong, M. A. Kaderali, S.-l. Xu, , M. S. Cyert

The paper identifies calcineurin (CN) substrates and interactors using a combination of experimental and computational methods, revealing novel roles for CN in regulating nuclear pore complex proteins.

bioRxiv · Mar 26, 2020Cell Biology