J. D. Lifson

Microglia and macrophages alterations in the CNS during acute SIV infection: a single-cell analysis in rhesus macaques

This study uses single-cell RNA sequencing to analyze microglia and macrophages in rhesus macaques during acute SIV infection, revealing changes in cell clusters and gene expression linked to inflammation and neurodegeneration.

The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection

This study examines how SIV-induced immunodeficiency affects SARS-CoV-2 infection in macaques, finding that while immune responses are impaired, viral kinetics and evolution remain unchanged.

Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.

Lymphoid tissues contribute to viral clonotypes present in plasma at early post-ATI in SIV-infected rhesus macaques

This study identifies secondary lymphoid tissues as a source of SIV clonotypes detected in plasma early after antiretroviral therapy interruption.

SIV clearance from neonatal macaques following transient CCR5 depletion

This study shows that targeted depletion of CCR5-expressing cells in neonatal macaques using bispecific antibodies can lead to long-term SIV remission and apparent cure.

Asymmetric HIV-1 envelope trimers bound to one and two CD4 molecules are intermediates during membrane binding

The paper uses cryo-ET to study HIV-1 Env-CD4 interactions on membranes, revealing asymmetric trimers bound to one or two CD4 molecules as intermediates in virus binding.

Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

This study identifies nAbs against SIVmac239, reveals structural features of its Env trimer, and shows passive transfer of nAbs protects macaques from infection.

A tyrosine-based trafficking signal in the simian immunodeficiency virus envelope cytoplasmic domain is strongly selected for in pathogenic SIV infection

This study shows that a tyrosine-based trafficking signal in SIV Env is strongly selected for during pathogenic infection, as mutations reconstitute endocytosis and polarized sorting signals.

New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure

This paper demonstrates that SHIVs with bulky aromatic amino acid substitutions at Env375 replicate efficiently in rhesus macaques and can be used for preclinical HIV vaccine testing.

Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy

This study identifies eight genes in two RhCMV regions that control unconventional CD8+ T cell responses and vaccine efficacy against SIV challenge.

Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy

This study shows that the Rh67/UL40 protein in RhCMV/SIV vectors is necessary for MHC-E-restricted CD8+ T cell responses and SIV protection in rhesus macaques.

Mucosal immune stimulation with HSV-2 and polyICLC boosts control of viremia in SIVΔNef vaccinated rhesus macaques with breakthrough SIV infection

This study investigates how HSV-2 and polyICLC immune stimulation affects SIV vaccine efficacy in rhesus macaques, finding that mucosal immune activation can enhance control of viremia in breakthrough infections.

Oral clade C SHIV challenge models to study pediatric HIV-1 infection by breastmilk transmission

This paper evaluates three clade C SHIVs for oral transmission and infection in infant rhesus macaques, finding varied chronic viremia levels and seroconversion thresholds.