R. V. Moriarty

Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.

CD8+ cells and small viral reservoirs facilitate post-ART control of SIV in Mauritian cynomolgus macaques

Host Immunity to Mycobacterium tuberculosis Infection is Similar in Simian Immunodeficiency Virus (SIV)-infected, Antiretroviral Therapy-treated and SIV-naïve Juvenile Macaques

This study compares host immunity to Mycobacterium tuberculosis in SIV-infected, ART-treated and SIV-naïve juvenile macaques, finding similar TB progression and T cell responses.

Control of SIV infection in prophylactically vaccinated, ART-naïve macaques is required for the most efficacious CD8 T cell response during treatment with the IL-15 superagonist N-803

This study shows that N-803 treatment enhances CD8 T cell responses in SIV-infected macaques with low viral set-points, but not in those without prior immune control.

Zika virus infection of pregnant Ifnar1-/- mice triggers strain-specific differences in fetal outcomes

This study compares fetal outcomes in pregnant Ifnar1-/- mice infected with different ZIKV strains, finding strain-specific differences in fetal demise rates.

Substrate, temperature, and geographical patterns among nearly 2,000 natural yeast isolates

The paper analyzes nearly 2,000 natural yeast isolates to identify geographic, substrate, and temperature patterns among yeast taxa.

Spontaneous control of SIV replication does not prevent immune dysregulation and bacterial dissemination in animals co-infected with M. tuberculosis

This study shows that SIV+ animals, regardless of viral control, have higher Mtb burden and dysregulated immune responses, leading to increased bacterial dissemination.

Pre-existing SIV infection increases expression of T cell markers associated with activation during early Mycobacterium tuberculosis co-infection and impairs TNF responses in granulomas

This study shows that pre-existing SIV infection alters T cell phenotypes and reduces TNF responses during early Mtb co-infection, impairing immune control.

Spondweni virus causes fetal harm in a mouse model of vertical transmission and is transmitted by Aedes aegypti mosquitoes

This study shows Spondweni virus causes fetal harm in mice and is transmitted by Aedes aegypti mosquitoes, similar to Zika virus.

Pathogenic Budding Yeasts Isolated outside of Clinical Settings

The paper isolates pathogenic budding yeasts from non-clinical environments, finding associations with fruits, soil, and plants, challenging the assumption that these yeasts are only contaminants.

Acute-phase CD4+ T cell responses targeting invariant viral regions are associated with control of live-attenuated simian immunodeficiency virus

This study shows that CD4+ T cell responses targeting invariant viral regions in MCMs without protective MHC alleles correlate with lower viral load during SIV infection.