N. M. Clark

Automated single-cell proteomics providing sufficient proteome depth to study complex biology beyond cell type classifications

This study presents an automated single-cell proteomics workflow that identifies over 4,000 proteins per cell and detects key regulatory proteins in LPS-perturbed THP-1 cells.

Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.

Transcription Factor Dynamics in Cross-Regulation of Plant Hormone Signaling Pathways

The paper constructs a cross-regulation network of plant hormone signaling pathways by analyzing transcription factor activity and dynamic regulatory models in Arabidopsis seedlings.

The Class VIII myosin ATM1 is required for root apical meristem function

This study shows ATM1, a Class VIII myosin, is essential for root apical meristem function, affecting cell proliferation and columella differentiation in response to auxin and sugar.

Integration of multi-omics data reveals interplay between brassinosteroid and TORC signaling in Arabidopsis

The paper integrates multi-omics data to uncover molecular interactions between BR and TORC signaling in Arabidopsis, revealing shared regulatory mechanisms in growth and stress responses.

Phosphorylation dynamics in a flg22-induced, heterotrimeric G-protein dependent signaling network in Arabidopsis thaliana reveals a candidate PP2A phosphatase involved in AtRGS1 trafficking

Anti-SARS-CoV-2 IgG and IgA antibodies in COVID-19 convalescent plasma do not facilitate antibody-dependent enhance of viral infection.

This study investigates whether antibodies in convalescent plasma enhance SARS-CoV-2 infection and finds no evidence of antibody-dependent enhancement by IgG or IgA isotypes.

Interplay between brassinosteroids and TORC signaling in Arabidopsis revealed by integrated multi-dimensional analysis

This study identifies crosstalk between brassinosteroid and TORC signaling in Arabidopsis through multi-omics analysis of mutants, revealing shared gene-products and a kinase signaling network.

Quantitative proteomics reveals extensive lysine ubiquitination in the Arabidopsis root proteome and uncovers novel transcription factor stability states

This study identifies 3,178 ubiquitinated proteins in Arabidopsis roots using a diGly enrichment method, revealing novel transcription factor stability regulation.

Integrated omics networks reveal the temporal signaling events of brassinosteroid response in Arabidopsis

This study integrates multi-omic data to construct a regulatory network of brassinosteroid response in Arabidopsis, identifying key phosphorylation sites and a novel transcription factor involved in cell division.

Protein complex stoichiometry and expression dynamics of transcription factors modulate stem cell division

The paper models SHR-SCR complex stoichiometry and regulation to explain differences in division timing between QC and CEI in Arabidopsis root stem cells.