C. O'Connor

Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell death

This study shows that stabilizing PP2A with a small molecule enhances DNA damage-induced apoptosis in HGSC cells and xenografts, both alone and with PARPi, by inhibiting HR and targeting RAD51.

Upregulated PD-1 Signaling is an Important Antagonist to Glomerular Health in Aged Kidneys

This study shows that upregulated PD-1 signaling in aged kidneys impairs podocyte health and that anti-PD-1 treatment improves podocyte aging and kidney function.

Genetic Architecture of Kernel Compositional Variation in a Maize Diversity Panel

This study identifies genetic loci associated with compositional traits in maize using GWAS, revealing significant genetic and environmental influences on grain quality.

Whole Genome Variation of Transposable Element Insertions in a Maize Diversity Panel

This study analyzes TE insertion polymorphisms across 509 maize inbred lines using short read sequencing, revealing patterns of TE frequency, nesting, and SNP tagging.

Cis-regulatory elements within TEs can influence expression of nearby maize genes

The paper identifies TE insertions that influence gene expression in maize by disrupting or carrying accessible chromatin regions, showing TEs can create novel regulatory elements.

Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling

This study shows that tuft cells suppress pancreatic tumorigenesis by producing anti-inflammatory prostaglandin D2, which inhibits stromal activation, and identifies their protective role in early disease progression.

Allele specific expression and methylation in the bumblebee, Bombus terrestris

This study investigates allele-specific expression and methylation in bumblebees, finding genes with monoallelic methylation and expression, and identifying allele-specific expression in RNA-seq libraries.