C. Yee

pan-MHC and cross-Species Prediction of T Cell Receptor-Antigen Binding

This paper develops pMTnet-omni, an AI system predicting TCR-pMHC binding across species and MHC classes, achieving high accuracy and showing clinical utility in predicting immune-related adverse events.

Model Parameter identification using 2D vs 3D experimental data: a comparative analysis

This paper compares parameter estimation in a computational model of ovarian cancer using 2D and 3D experimental data to assess the impact of experimental settings on model calibration and validation.

Immunogenic SARS-CoV2 Epitopes Defined by Mass Spectrometry

This study identifies novel SARS-CoV-2 epitopes using mass spectrometry and validates their immunogenicity by T cell recognition.

In Silico Defined SARS-CoV2 Epitopes May Not Predict Immunogenicity to COVID19

This study shows that in silico predicted SARS-CoV-2 epitopes do not reliably elicit T cell responses against naturally presented epitopes.

Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2

This study develops an intranasal vaccine that induces systemic and mucosal immunity against SARS-CoV-2 in mice, with single-cell RNA-sequencing confirming T and B cell responses in nasal-associated lymphoid tissues.

Coffee consumption and risk of breast cancer: a Mendelian Randomization study

This study uses Mendelian randomization to assess coffee consumption's effect on breast cancer risk, finding no significant association.

Immune landscape of a genetically-engineered murine model of glioma relative to human glioma by single-cell sequencing

This study compares the immune landscape of a genetically-engineered murine glioma model to human glioma using single-cell sequencing, finding similar immunosuppressive features but differences in immune cell composition between mouse models and human samples.

Proteomic changes in bacteria caused by exposure to environmental conditions can be detected by Matrix-Assisted Laser Desorption/Ionization - Time of Flight (MALDI-ToF) Mass Spectrometry

This study shows that MALDI-ToF MS can detect proteomic changes in bacteria exposed to different environmental conditions, revealing intra-species phenotypic differences.

The Role of CD147 in Leukocyte Aggregation in Liver Injury

This study identifies CD147 as a mediator of leukocyte aggregation in liver injury, showing that blocking CD147 reduces aggregate formation and liver damage without affecting overall leukocyte numbers.

Selective inhibition of HDAC3 targets synthetic vulnerabilities and activates immune surveillance in lymphoma

This paper shows that HDAC3 inhibitors reverse CREBBP mutation-driven epigenetic changes in lymphoma, inhibiting tumor growth and restoring immune surveillance.