Author

A. B. Heimberger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3

Frequent Co-Authors

C. Kassab· 2 shared P. J. Dickinson· 2 shared A. Ahmed· 1 shared A. Ashworth· 1 shared A. Bhaduri· 1 shared A. Choudhury· 1 shared A. D. Miller· 1 shared A. Goldman· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

C. Kassab

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Author profile →

5 papers

Recent·Most cited

NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy

A. Choudhury, M. A. Cady, C.-H. G. Lucas, H. Najem, J. J. Phillips, B. Palikuqi, N. Zakimi, T. Joseph, J. O. Birreuta, W. C. Chen, N. A. O. Bush, S. L. Hervey-Jumper, O. D. Klein, C. M. Toedebusch, C. M. Horbinski, , D. R. Raleigh

This study identifies NOTCH3 as a driver of meningioma tumorigenesis and radiotherapy resistance, showing its role in tumor growth and survival in preclinical models.

bioRxiv · Jul 10, 2023 · PreprintCancer Biology

Immune Contexture of Isocitrate Dehydrogenase stratified Human Gliomas

P. Gupta, M. Dang, S. Oberai, M. M. Peshoff, N. Milam, A. Ahmed, K. Bojja, T. M. Tran, K. Cox, H. Shehwana, C. K. Matsuoka, J. Li, J. Gumin, A. Goldman, S. A. Seth, , K. P. Bhat

The paper provides a comprehensive analysis of immune contexture in IDH stratified human gliomas using single-cell RNA sequencing and spectral cytometry, identifying TREM2 as a novel immunotherapy target.

bioRxiv · Nov 8, 2022Immunology

Immune landscape of a genetically-engineered murine model of glioma relative to human glioma by single-cell sequencing

D. B. Zamler, T. Shingu, L. M. Kahn, C. Kassab, M. Ott, K. Tomczak, J. Liu, Y. Li, I. P. Lai, C. Yee, K. Rai, A. B. Heimberger, G. Draetta, J. Hu

This study compares the immune landscape of a genetically-engineered murine glioma model to human glioma using single-cell sequencing, finding similar immunosuppressive features but differences in immune cell composition between mouse models and human samples.

bioRxiv · May 11, 2020 · PreprintCancer Biology

CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas

J. R. Kane, J. Zhao, T. Tsujiuchi, B. Laffleur, A. Mahajan, G. Rao, A. Mela, C. Dmello, V. A. Arrieta, L. Chen, D. Y. Zhang, E. Gonzalez-Buendia, C. Lee-Chang, T. Xiao, G. Rothschild, , A. M. Sonabend

This study shows that CD8+ T-cells mediate immunoediting in murine gliomas, affecting genomic stability and immune evasion.

bioRxiv · Jul 16, 2019Cancer Biology

Comparative molecular life history of spontaneous canine and human gliomas

S. B. Amin, K. J. Anderson, C. E. Boudreau, E. Martinez-Ledesma, E. Kocavakuk, K. C. Johnson, F. P. Barthel, F. S. Varn, C. Kassab, X. Ling, H. Kim, M. Barter, C. Y. Ngan, M. Chapman, J. W. Koehler, , R. G. Verhaak

This study compares molecular profiles of canine and human gliomas to identify conserved mutational processes and similarities in tumor development.

bioRxiv · Jun 17, 2019Cancer Biology