Author

Y. Kirichok

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2

Frequent Co-Authors

J. Suzuki· 3 shared A. M. Bertholet· 2 shared N. Chatterjee· 2 shared V. Olivas· 2 shared W. Wu· 2 shared A. J. Sabnis· 1 shared A. L. Gunawan· 1 shared A. Stahl· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

J. Suzuki

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mitochondrial uncouplers impair human sperm motility without altering ATP content

W. M. Skinner, N. T. Petersen, B. Unger, S. Tang, E. Tabarsi, J. Lamm, L. Jalalian, J. Smith, A. M. Bertholet, K. Xu, Y. Kirichok, P. V. Lishko

This study shows mitochondrial uncouplers impair human sperm motility without reducing ATP content, suggesting ATP-independent mechanisms and potential contraceptive applications.

bioRxiv · Aug 4, 2022Cell Biology

Coenzyme Q regulates UCP1 expression and thermogenesis through the integrated stress responses

C.-F. Chang, A. L. Gunawan, P.-J. H. Zushin, G. A. Timblin, A. M. Bertholet, B. Wang, K. Saijo, Y. Kirichok, A. Stahl

This study shows that CoQ deficiency in BAT activates the ISR and suppresses UCP1, yet increases whole-body metabolic rates and reduces weight gain on HFD.

bioRxiv · Mar 18, 2022 · PreprintCell Biology

Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR mutant lung cancer

S. Nanjo, W. Wu, N. Karachaliou, C. Blakely, J. Suzuki, S. Ali, L. Kerr, V. Olivas, J. Shue, J. Rotow, M. Mayekar, F. Haderk, N. Chatterjee, A. Urisman, Y. Kirichok, , T. Bivona

This study shows that RBM10 deficiency reduces EGFR inhibitor efficacy in EGFR mutant lung cancer by altering Bcl-x splicing and apoptosis, and that co-inhibiting Bcl-xL can overcome this resistance.

bioRxiv · Oct 26, 2020 · PreprintCancer Biology

The Mechanism of MICU-Dependent Gating of theMitochondrial Ca2+ Uniporter

V. Garg, I. Paranjpe, T. Unsulangi, J. Suzuki, L. S. Milescu, Y. Kirichok

The paper uses patch-clamp analysis to show MICUs do not occlude the mitochondrial Ca2+ uniporter but enhance its activity with elevated cytosolic Ca2+.

bioRxiv · Apr 4, 2020Biophysics

Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

N. Chatterjee, E. Pazarentzos, G. Hrustanovic, L. Lin, E. Verschueren, J. R. Johnson, M. Hofree, J. J. Yan, V. Olivas, B. W. Newton, J. V. Dollen, C. H. Earnshaw, J. Flanagan, E. Chan, S. Asthana, , T. G. Bivona

The paper identifies PDHK1 as a synthetic-essential gene in PTEN-deficient cells and cancers, showing its upregulation drives aerobic glycolysis and correlates with poor patient survival.

bioRxiv · Oct 11, 2018Cancer Biology