Author

C.-W. Chiang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

B. K. Law· 2 shared E. Yaaghubi· 2 shared M. E. Law· 2 shared M. Wang· 2 shared R. K. Castellano· 2 shared A. Franceschini Ghilardi· 1 shared A. Ghilardi· 1 shared A. Sharma· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

B. K. Law

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An Accessible and Scalable Pipette-Driven Microfluidic Platform for Lipid Nanoparticle Formulation

Y. S. Takeda, F. Wang, X. Gu, J. Forster, H. Hou, P. Hemmati, B. Partopour, L. Maugeri, Y. Kim, S. Apel, R. Norton, J. Finelli, P. Molaei, S. Shafiee, S. Li, , Mehdi Dehghani

This paper introduces a microfluidic platform for lipid nanoparticle formulation that improves scalability and efficiency in mRNA delivery.

bioRxiv · Nov 9, 2026 · PreprintBioengineering

DR5 disulfide bonding as a sensor and effector of protein folding stress

M. E. Law, Z. M. Dulloo, S. R. Eggleston, G. P. Takacs, G. M. Alexandrow, M. Wang, H. Su, B. A. Forsyth, C.-W. Chiang, A. Sharma, S. R. R. Kanumuri, O. A. Guryanova, J. K. Harrison, B. Tirosh, R. K. Castellano, B. K. Law

This study shows that disrupting DR5 disulfide bonds activates pro-apoptotic signaling and reveals DR5 disulfide bonding as a sensor and effector of ER stress in cancer cells.

bioRxiv · Mar 4, 2024 · PreprintCancer Biology

Inhibitors of ERp44, PDIA1, and AGR2 induce disulfide-mediated oligomerization of Death Receptors 4 and 5 and cancer cell death

M. E. Law, E. Yaaghubi, A. Ghilardi, B. J. Davis, R. B. Ferreira, J. Koh, S. Chen, S. F. DePeter, C. M. Schilson, C.-W. Chiang, C. D. Heldermon, P. Norgaard, R. K. Castellano, B. K. Law

This study identifies DDAs as inhibitors of AGR2 and ERp44, showing they induce DR4/5 oligomerization and cancer cell death via disrupting disulfide bonds.

bioRxiv · Jan 13, 2021Pharmacology & Toxicology

Mechanistic Elucidation of the Antitumor Properties of a Novel Death Receptor 5 Activator

M. Wang, M. Law, B. Davis, E. Yaaghubi, A. Franceschini Ghilardi, R. Ferreira, C.-W. Chiang, O. Guryanova, D. Kopinke, C. Heldermon, R. Castellano, B. Law

This study identifies DDAs as compounds that upregulate DR5 in cancer cells, leading to apoptosis and synergy with TRAIL, with selectivity for oncogene-transformed cells.

bioRxiv · Jul 14, 2019 · PreprintCancer Biology