Molecular basis for chikungunya virus recognition of a mosquito-specific receptor
Xiaoyi Fan, Wanyu Li, Jesse S. Plung, Jessica A. Plante, Ellie M. Hajovsky, Nisha Tapryal, Jennifer Diaz, Nicholas C. Hazell, Chenggong Ji, Zhiqi Liu, Catherine E. Hammond, Scott C. Weaver, Kenneth S. Plante, Jonathan Abraham
This study identifies the molecular basis of chikungunya virus recognition of the mosquito-specific receptor Lachesin using cryo-EM structures and shows a Lachesin polymorphism that blocks virus entry.
bioRxiv · Jul 29, 2026 · PreprintMicrobiology