Author

Christopher A. Smith

Wellcome/MRC Institute of Metabolic Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Adam Davison· 1 shared Ahmed ShaabaniD· 1 shared André GörgensiD· 1 shared Angharad E. Evans· 1 shared Callum D.W. Daniel· 1 shared Constanza AlcainoiD· 1 shared Cordelia ImigiD· 1 shared Daniel A. Lonergan· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

Adam Davison

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Author profile →

2 papers

Recent·Most cited

Efficient genome editing in the non-human primate brain using programmable extracellular vesicles

Xiuming Liang, Houze Zhou, Zubair Ahmed Nizamudeen, Eleni Kyriakopoulou, Angharad E. Evans, Samantha Roudi, Hernando Yesid Estupiñan, Julia Rädler, Vincent Hou, Callum D.W. Daniel, Inés Hernández-Pérez, Malika Singh, Pardis Parsi, Daniel A. Lonergan, Lidia Menéndez Berlana, , Samir EL Andaloussi

This paper demonstrates efficient genome editing in non-human primate brains using engineered extracellular vesicles, achieving therapeutic potential for neurological disorders.

bioRxiv · Aug 6, 2026 · PreprintMolecular Biology

Mechanisms of Activation and Serotonin release from Human Enterochromaffin Cells

Constanza Alcaino, Nunzio Guccio, Emily L. Miedzybrodzka, Jaden R Quale, Tianyi Lu, Adam Davison, Christopher A. Smith, Emily Overington, Marta Santos-Hernández, Mae Tabbada, Megan Hodge, Rula Bany Bakar, Richard G. Kay, Ahmed Shaaban, Cordelia Imig, , Fiona Mary Gribble

This study investigates mechanisms of serotonin release from human enterochromaffin cells using organoids and functional assays, identifying key receptors and signaling pathways involved.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2025Peer-reviewedCell Biology