Author

D. C. Newcomb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Sugiura· 2 shared C. Chi· 2 shared J. Rathmell· 2 shared M. M. Wolf· 2 shared X. Ye· 2 shared A. E. Dikalova· 1 shared A. I. Sperling· 1 shared B. W. Richmond· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

A. Sugiura

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tissue-Specific Dependence of Th1 Cells on the Amino Acid Transporter SLC38A1 in Inflammation

A. Sugiura, K. Beier, C. Chi, D. Heintzman, X. Ye, M. M. Wolf, J.-Y. C. Cephus, H. Hong, C. A. Lyssiotis, D. C. Newcomb, J. Rathmell

This study identifies tissue- and subset-specific roles of SLC38A1 in Th1 cell function during inflammation, showing its importance in EAE and IBD but not lung inflammation.

bioRxiv · Sep 13, 2023 · PreprintImmunology

Repetitive Sulfur Dioxide Exposure in Mice Models Post-Deployment Respiratory Syndrome

S. S. Gutor, R. I. Salinas, D. S. Nichols, J. M. R. Bazzano, W. Han, J. J. Gokey, G. Vasiukov, J. D. West, D. C. Newcomb, A. E. Dikalova, B. W. Richmond, S. I. Dikalov, T. S. Blackwell, V. V. Polosukhin

This study develops a mouse model of repetitive sulfur dioxide exposure that mimics post-deployment respiratory syndrome features, identifying oxidative stress as a mediator of pulmonary vascular disease.

bioRxiv · May 15, 2023Pathology

Androgen Signaling Restricts Glutaminolysis to Drive Sex-Specific Th17 Metabolism

N. U. Chowdhury, J.-Y. Cephus, M. Z. Madden, M. M. Wolf, C. Chi, A. Sugiura, M. T. Stier, K. Voss, X. Ye, S. N. Kuehnle, K. Scales, V. D. Gandhi, R. D. Guzy, K. N. Cahill, A. I. Sperling, , D. C. Newcomb

The paper shows that androgen signaling reduces glutaminolysis in male Th17 cells, leading to sex-specific metabolic differences that affect Th17-mediated inflammation.

bioRxiv · Feb 10, 2023 · PreprintImmunology