Author

M. Z. Madden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. M. Wolf· 3 shared B. I. Reinfeld· 2 shared J. C. Rathmell· 2 shared J. E. Bader· 2 shared K. E. Beckermann· 2 shared W. K. Rathmell· 2 shared X. Ye· 2 shared A. Abraham· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersImmunology

M. M. Wolf

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3 papers

Recent·Most cited

Androgen Signaling Restricts Glutaminolysis to Drive Sex-Specific Th17 Metabolism

N. U. Chowdhury, J.-Y. Cephus, M. Z. Madden, M. M. Wolf, C. Chi, A. Sugiura, M. T. Stier, K. Voss, X. Ye, S. N. Kuehnle, K. Scales, V. D. Gandhi, R. D. Guzy, K. N. Cahill, A. I. Sperling, , D. C. Newcomb

The paper shows that androgen signaling reduces glutaminolysis in male Th17 cells, leading to sex-specific metabolic differences that affect Th17-mediated inflammation.

bioRxiv · Feb 10, 2023 · PreprintImmunology

PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity

J. E. Bader, M. M. Wolf, M. Z. Madden, B. I. Reinfeld, E. N. Arner, E. S. Hathaway, K. K. Steiner, G. A. Needle, M. D. Landis, M. A. Cottam, X. Ye, A. Christofides, V. A. Boussiotis, S. M. Haake, K. E. Beckermann, , J. C. Rathmell

This study shows obesity induces PD-1 on tumor-associated macrophages, which suppresses anti-tumor immunity by altering metabolic and functional properties of these cells.

bioRxiv · Nov 12, 2022 · PreprintImmunology

Cell Programmed Nutrient Partitioning in the Tumor Microenvironment

B. I. Reinfeld, M. Z. Madden, M. M. Wolf, A. Chytil, J. E. Bader, A. R. Patterson, A. S. Cohen, A. Ali, B. T. Do, C. A. Lewis, A. Muir, R. A. Hongo, K. L. Young, R. E. Brown, V. M. Todd, , W. K. Rathmell

The paper measures nutrient uptake in the tumor microenvironment using PET tracers and finds cancer cells prefer glutamine while myeloid cells consume most glucose.

bioRxiv · Aug 10, 2020 · PreprintCancer Biology