D. F. Tifrea

Cross-Protection Induced by Highly Conserved Human B, CD4+, and CD8+ T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of Concern

This paper describes a multi-epitope vaccine that provides cross-protection against multiple SARS-CoV-2 variants by inducing functional T cell responses.

Anti-Viral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein Against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models

This study shows RAGE-Ig reduces viral replication and inflammation in multiple SARS-CoV-2 variants using animal models and human cells.

High Frequencies of PD-1+TIM3+TIGIT+CTLA4+ Functionally Exhausted SARS-CoV-2-Specific CD4+ and CD8+ T Cells Associated with Severe Disease in Critically ill COVID-19 Patients

Predicting COVID-19 Severity with a Specific Nucleocapsid Antibody plus Disease Risk Factor Score

This paper identifies an antibody epitope and a risk score to predict severe COVID-19 outcomes with high specificity.

Genome-Wide Asymptomatic B-Cell, CD4+ and CD8+ T-Cell Epitopes, that are Highly Conserved Between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Immune Targets for Pre-Emptive Pan-Coronavirus Vaccines

The paper identifies conserved B-cell and T-cell epitopes across multiple Coronaviruses to inform the development of a pan-Coronavirus vaccine.

Disrupting β-catenin dependent Wnt signaling activates an invasive gene program predictive of colon cancer progression

This study shows that reducing Wnt signaling in colon cancer cells increases their invasiveness and identifies gene markers predictive of poor patient outcomes.