D. Horst

Super-enhancer-driven CACNA2D2 is an EWSR1::WT1 signature gene encoding a diagnostic marker for desmoplastic small round cell tumor (DSRCT)

The paper identifies CACNA2D2 as a super-enhancer-driven target of EWSR1::WT1 and demonstrates its utility as a diagnostic biomarker for DSRCT.

Reporter-based screening identifies RAS-RAF stabilizing mutations as drivers of resistance to broad-spectrum RAS inhibition in colorectal cancer

A quantitative tumor-wide analysis of morphological heterogeneity of colorectal adenocarcinoma

The paper quantitatively analyzes morphological heterogeneity in colorectal adenocarcinoma, finding that specific morphotypes correlate with clinical outcomes.

High-confidence calling of normal epithelial cells allows identification of a novel stem-like cell state in the colorectal cancer microenvironment

The paper develops CCISM to distinguish cancer cells from normal epithelial cells in single-cell data, identifying a novel stem-like cell state in the colorectal cancer microenvironment.

Teacher-student collaborated multiple instance learning for pan-cancer PDL1 expression prediction from histopathology slides

The paper develops MILTS, a teacher-student framework for predicting PDL1 expression from H&E slides using weakly supervised learning, achieving high AUC scores across multiple tumor types.

Robust detection of clinically relevant features in single-cell RNA profiles of patient-matched fresh and formalin-fixed paraffin-embedded (FFPE) lung cancer tissue

The paper compares single-cell RNA sequencing from fresh, cryopreserved, and FFPE lung cancer tissues, finding FFPE tissues can reliably detect clinically relevant features.

Patient-derived tumoroids of advanced high-grade neuroendocrine neoplasms mimic patient chemotherapy responses and guide the design of personalized combination therapies

The paper develops patient-derived tumoroids to predict chemotherapy responses and identify synergistic drug combinations for high-grade GEP-NEN.

The single-cell transcriptional landscape of lung carcinoid tumors

This study uses single-cell RNA sequencing to analyze lung carcinoid tumors, revealing their cellular composition, gene expression profiles, and potential therapeutic targets.

Archival influenza virus genomes from Europe reveal genomic and phenotypic variability during the 1918 pandemic

Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma

The paper uses single-cell RNA sequencing to identify two distinct tumor microenvironmental patterns in lung adenocarcinoma, associated with different prognostic outcomes.

DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas (PanNECs) and pancreatic neuroendocrine tumors (PanNETs)

The paper uses DNA methylation analysis to distinguish high-grade PanNECs from other PanNETs, revealing an exocrine cell of origin for PanNECs.

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer

The paper identifies mitogen-activated protein kinase activity as a driver of cell trajectories in colorectal cancer using single-cell transcriptomics and organoid models.

The history of measles: from a 1912 genome to an antique origin

The paper sequences a 1912 measles virus genome and uses molecular clock modeling to estimate measles virus divergence from rinderpest virus as early as the 4th century BCE.