Author

F. Uhlitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 6 Research Focus:differential expression· 5 Organism:human· 5 Assay:whole-genome sequencing· 4 Research Focus:cell type annotation· 3 Research Focus:clustering· 3 Assay:scRNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

E. Havasov· 4 shared M. J. Williams· 4 shared N. Ceglia· 4 shared N. Rusk· 4 shared A. C. Weiner· 3 shared A. W. Zhang· 3 shared D. Grewal· 3 shared I. Vazquez-Garcia· 3 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

E. Havasov

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer

A. W. McPherson, I. Vazquez-Garcia, M. A. Myers, M. Zatzman, D. H. Al-Rawi, A. C. Weiner, S. S. Freeman, N. Mohibullah, G. Satas, M. J. Williams, N. Ceglia, A. W. Zhang, J. Li, J. L. P. Lim, M. Wu, , Ellenso

This study shows that ongoing whole-genome doubling in ovarian cancer promotes cell diversity and immune dysregulation through chromosomal instability and quiescent states.

bioRxiv · Jul 11, 2024 · PreprintCancer Biology

Immune and malignant cell phenotypes of ovarian cancer are determined by distinct mutational processes

I. Vazquez-Garcia, F. Uhlitz, N. Ceglia, J. L. P. Lim, M. Wu, N. Mohibullah, A. E. B. Ruiz, K. M. Boehm, V. Bojilova, C. J. Fong, T. Funnell, D. Grewal, E. Havasov, S. Leung, A. Pasha, , Nikolovsk

This study identifies distinct immune and malignant cell phenotypes in ovarian cancer linked to specific mutational processes and anatomic sites.

bioRxiv · Aug 24, 2021Cancer Biology

Evolutionary tracking of cancer haplotypes at single-cell resolution

M. J. Williams, T. Funnell, C. O'Flanagan, A. McPherson, S. Salehi, I. Vazquez-Garcia, F. Kabeer, H. Lee, T. Masud, P. Eirew, D. Yap, B. Wang, J. Brimhall, J. Biele, J. Ting, , S. P. Shah

The paper tracks cancer haplotypes at single-cell resolution, revealing allele-specific alterations and their role in structural variation evolution in human tumors.

bioRxiv · Jun 4, 2021 · PreprintCancer Biology

The impact of mutational processes on structural genomic plasticity in cancer cells

T. Funnell, C. H. O'Flanagan, M. J. Williams, A. McPherson, S. McKinney, F. Kabeer, H. Lee, T. Masud, P. Eirew, D. Yap, A. W. Zhang, J. L. P. Lim, B. Wang, J. Brimhall, J. Biele, , S. Aparicio

The paper analyzes structural genomic variations in cancer cells to understand how mutational processes influence cell-to-cell genomic diversity and tumor evolution.

bioRxiv · Jun 3, 2021 · PreprintCancer Biology

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer

F. Uhlitz, P. Bischoff, S. Peidli, A. Sieber, B. Obermayer, E. Blanc, A. Trinks, M. Luethen, Y. Ruchiy, T. Sell, S. Mamlouk, R. Arsie, T.-T. Wei, K. Klotz-Noack, R. Schwarz, , M. Morkel

The paper identifies mitogen-activated protein kinase activity as a driver of cell trajectories in colorectal cancer using single-cell transcriptomics and organoid models.

bioRxiv · Jan 10, 2020Cancer Biology

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium

R. Brandt, T. Sell, M. Luethen, F. Uhlitz, B. Klinger, P. Riemer, C. Giesecke, S. Schulze, I. A. El-Shimy, D. Kunkel, B. Fauler, T. Mielke, N. Mages, B. G. Herrmann, C. Sers, , M. Morkel

The paper investigates how oncogenic KRAS and BRAF differentially activate ERK in colon cancer and intestinal epithelium, revealing cell type-specific effects and novel regulatory mechanisms.

bioRxiv · Feb 14, 2019Cell Biology