Author

D. J. Mahoney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

F. J. Zemp· 3 shared A. Abdelkareem· 2 shared D. L. Senger· 2 shared N. H. Dang· 2 shared S. Morrissy· 2 shared S. Sikdar· 2 shared A. Gillmor· 1 shared A. J. Lazar· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

F. J. Zemp

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma

V. Thoppey Manoharan, A. Abdelkareem, S. Brown, A. Gillmor, C. Hall, H. Seo, K. Narta, S. Grewal, N. H. Dang, B. Y. Ahn, K. Otz, X. Lun, L. Mah, F. J. Zemp, D. J. Mahoney, , S. Morrissy

The paper uses a novel computational workflow to analyze a spatiotemporally profiled GBM xenograft cohort, identifying 15 tumor cell programs related to invasion and their prognostic significance in GBM patients.

bioRxiv · Dec 5, 2023Cancer Biology

ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97

A. Pozner, S. P. Verma, L. Li, S. Wang, J. J. Barrott, M. L. Nelson, J. S. E. Yu, G. L. Negri, S. Colborne, C. S. Hughes, J.-F. Zhu, S. L. Lambert, L. S. Carroll, K. Smith-Fry, M. G. Stewart, , K. B. Jones

This study identifies VCP/p97 as an obligate co-factor of ASPSCR1-TFE3, showing it organizes enhancer loops to drive oncogenic transcription in ASPS and RCC.

bioRxiv · Sep 29, 2023Cancer Biology

The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells

G. A. Gonzales, S. Huang, J. Rajwani, L. Wilkinson, J. A. Nguyen, C. M. Wood, I. Dinh, M. Moore, E. Cedeno, S. Sikdar, N. McKenna, V. Ebacher, N. L. Rosin, M. B. Carneiro, B. Surewaard, , J. Canton

This study identifies APOL7C as a pore-forming protein that facilitates phagosomal rupture and antigen cross-presentation by cDC1s.

bioRxiv · Aug 11, 2023Cell Biology

Booster vaccines protect hamsters with waning immunity from Delta VOC infection, disease, and transmission

K. G. Potts, R. S. Noyce, C. Gafuik, C. M. John, H. M. Todesco, E. De Heuvel, N. Favis, M. M. Kelly, D. H. Evans, D. J. Mahoney

bioRxiv · Dec 27, 2021 · PreprintImmunology

High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma

M. J. Johnston, A. Nikolic, N. Ninkovic, P. Guilhamon, F. M. Cavalli, S. Seaman, F. J. Zemp, J. Lee, A. Abdelkareem, K. Ellestad, A. Murison, M. M. Kushida, F. J. Coutinho, Y. Ma, A. J. Mungall, , M. Gallo

This study uses high-resolution 3D genome maps to identify CD276 as a therapeutic target in glioblastoma stem cells, showing it can suppress self-renewal.

bioRxiv · Oct 13, 2018Cancer Biology