Author

P. Saavedra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1

Frequent Co-Authors

A. Trzeciak· 2 shared J. I. Etchegaray· 2 shared W. S. Rojas· 2 shared A. Baako· 1 shared A. Lipschutz· 1 shared B. Spiegelman· 1 shared C. D. Lucas· 1 shared C. Lucas· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersImmunology

A. Trzeciak

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Early life high fructose exposure disrupts microglia function and impedes neurodevelopment

Z. Wang, A. Lipschutz, Z.-L. Liu, A. Trzeciak, I. Miranda, C. Martinez de la Torre, T. Schild, T. Lazarov, W. S. Rojas, P. Saavedra, J. Romero-Pichardo, A. Baako, F. Geissmann, G. Faraco, L. Gan, , J. Perry

This study shows that early life high fructose exposure impairs microglia function and neurodevelopment, with GLUT5 deletion reversing these effects.

bioRxiv · Aug 14, 2023 · PreprintImmunology

Novel adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments

Y.-T. Wang, A. Trzeciak, W. S. Rojas, P. Saavedra, Y.-T. Chen, R. Chirayil, J. I. Etchegaray, C. D. Lucas, D. J. Puleston, K. R. Keshari, J. S. A. Perry

This study identifies two macrophage states induced by chronic hypoxia that enhance efferocytosis through metabolic and transcriptional adaptations.

bioRxiv · Aug 4, 2022Immunology

REPTOR/CREBRF encode key regulators of muscle energy metabolism

P. Saavedra, P. A. Dumesic, Y. Hu, P. Jouandin, R. Binari, S. Wilensky, E. Filine, J. Rodiger, H. Wang, B. Spiegelman, N. Perrimon

This study identifies REPTOR/CREBRF as key regulators of muscle energy metabolism, showing they repress glycolysis and promote oxidative phosphorylation in both flies and mammals.

bioRxiv · Dec 17, 2021Physiology