R. S. Welner

Prenatal inflammation reprograms hyperactive ILC2s that promote allergic lung inflammation and airway dysfunction

Prenatal inflammation induces hyperactivated ILC2s in the developing lung, leading to increased asthma susceptibility through immune remodeling.

Fixation Before Dissociation Using a Deep Eutectic Solvent Preserves In Vivo States and Phospho-Signaling in Single-Cell Sequencing

This study introduces a deep eutectic solvent fixation method that preserves in vivo cellular states and phospho-signaling for scRNA-seq, enabling the identification of hyperactivated Th17 T cells.

Core binding factor leukemia hijacks T-cell prone PU.1 antisense promoter

The paper shows that CBF fusions in AML activate the PU.1 antisense promoter, reducing sense PU.1 transcription and blocking myeloid differentiation, similar to T-cell differentiation.

Transcription factor PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

This study shows that PU.1 enforces HSC quiescence by repressing protein synthesis and cell cycle genes, preventing clonal expansion during inflammatory stress.

Selective LXR agonist, DMHCA, corrects the retina-bone marrow axis in type 2 diabetes

This study shows that DMHCA, a selective LXR agonist, corrects the retina-bone marrow axis in type 2 diabetes by restoring retinal function, cholesterol homeostasis, and hematopoietic stem cell balance.