A. G. Goodman

Caspase-8 activity mediates TNFα production and restricts Coxiella burnetii replication during murine macrophage infection

This study investigates how caspase-8 regulates TNFα production and restricts Coxiella burnetii replication in macrophages during infection.

Insulin-mediated endothelin signaling is antiviral during West Nile virus infection

This study identifies insulin-mediated endothelin signaling as an antiviral pathway that reduces West Nile virus replication in both Drosophila and human cells.

The unfolded protein response triggers the immune deficiency pathway in ticks

The study shows that the unfolded protein response (UPR) initiates the immune deficiency (IMD) pathway in ticks, linking ER stress to pathogen restriction.

Coupled small molecules target RNA interference and JAK/STAT signaling to reduce Zika virus infection in Aedes aegypti

This study shows that repurposed small molecules activate both RNA interference and JAK/STAT antiviral pathways in Aedes aegypti, significantly reducing Zika virus levels.

Nuclear biocondensate-forming lncRNA and cellular stress surveillance shape host cancer susceptibility

This study identifies hsr{omega} and its human homologs as key regulators of cancer susceptibility through stress response pathways in Drosophila and humans.

Insulin potentiates JAK/STAT signaling to broadly inhibit flavivirus replication in insect vectors

This study identifies insulin-like receptor as a novel immune component in insects, showing insulin signaling inhibits flavivirus replication via JAK/STAT pathway activation in Drosophila and mosquitoes.