Author

D. P. O'Brien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Biophysics· 1 Cell Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:proteomics· 5 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. M. Kessler· 4 shared A. Pinto-Fernandez· 2 shared A. C. Myall· 1 shared A. Chanthongthip· 1 shared A. Chenal· 1 shared A. Dubot-Peres· 1 shared A. Haouz· 1 shared A. Kumar· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

B. M. Kessler

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

USP16 is an ISG15 cross-reactive deubiquitinase targeting a subset of metabolic pathway-related proteins

J. Gan, A. Pinto-Fernandez, D. Flierman, J. J. L. L. Akkermans, D. P. O'Brien, H. Greenwood, H. C. Scott, J. Neefjes, G. Fritz, K.-P. Knobeloch, H. van Dam, B. M. Kessler, H. Ovaa, P. P. Geurink, A. Sapmaz

This study identifies USP16 as an ISG15 cross-reactive deubiquitinase that regulates metabolic pathway-related proteins during type I interferon responses.

bioRxiv · Jun 26, 2023 · PreprintBiochemistry

Novel protein interaction network of human calcitonin receptor-like receptor revealed by label-free quantitative proteomics

D. Manolis, S. Hasan, C. Ettelaie, A. Maraveyas, D. P. O'Brien, B. M. Kessler, H. B. Kramer, L. L. Nikitenko

The paper identifies 46 novel proteins interacting with CLR in primary human dermal lymphatic endothelial cells using immunoprecipitation and mass spectrometry, confirmed by proximity ligation assay.

bioRxiv · Apr 18, 2023Cell Biology

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

D. P. O'Brien, H. B. Jones, F. Guenther, E. J. Murphy, K. S. England, M. Anderson, P. Brennan, J. B. Davis, A. Pinto-Fernandez, A. P. Turnbull, B. M. Kessler

This study investigates how a benzosulfonamide compound inhibits USP30, a mitochondrial deubiquitylating enzyme, using biochemical and structural methods to reveal its binding mechanism and selectivity.

bioRxiv · Sep 13, 2022Biochemistry

Deep proteomics network and machine learning analysis of human cerebrospinal fluid in Japanese encephalitis virus infection

T. Bharucha, B. Gangadharan, A. Kumar, A. C. Myall, N. Ayhan, B. Pastorino, A. Chanthongthip, M. Vongsouvath, M. Mayxay, O. Sengvilaipaseuth, S. Rattanavong, D. P. O'Brien, I. Vendrell, R. Fischer, B. Kessler, , SEAe collaborators

This study identifies a ten-protein diagnostic signature for Japanese encephalitis virus infection in cerebrospinal fluid with >99% accuracy using proteomics and machine learning.

bioRxiv · Jun 19, 2022Microbiology

Integrative Omics Reveals Subtle Molecular Perturbations Following Ischemic Conditioning in a Porcine Kidney Transplant Model

D. P. O'Brien, A. M. Thorne, H. Huang, E. Pappalardo, X. Yao, P. Soendergaard Thyrrestrup, K. R. Ravlo, N. S. Secher, R. N. Norregaard, R. J. Ploeg, B. Jespersen, B. M. Kessler

This study uses integrative omics to detect subtle molecular changes in porcine kidneys after remote ischemic conditioning, finding reduced inflammation and potential fibrosis markers.

bioRxiv · Apr 23, 2021Physiology

A high-affinity calmodulin-binding site in the CyaA toxin translocation domain is essential for invasion into eukaryotic cells

A. Voegele, M. Sadi, D. P. O'Brien, P. Gehan, D. Raoux-Barbot, M. Davi, S. Hoss, S. Brule, B. Raynal, P. Weber, A. Mechaly, A. Haouz, N. Rodriguez, P. Vachette, D. Durand, , A. Chenal

bioRxiv · Sep 14, 2020Biophysics