Author

D. R. Raleigh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

A. Choudhury· 3 shared W. C. Chen· 3 shared A. Perry· 2 shared H. N. Vasudevan· 2 shared O. D. Klein· 2 shared S. L. Hervey-Jumper· 2 shared S. T. Magill· 2 shared A. Ashworth· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

A. Choudhury

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.

H. N. Thirimanne, D. A. Bonnin, N. Nuechterlein, S. Arora, M. Jensen, C. A. Parada, C. Qiu, F. Szulzewsky, C. W. English, W. C. Chen, P. Sievers, F. Nassiri, J. Z. Wang, T. J. Klisch, K. D. Aldape, , E. C. Holland

This study combines bulk RNA-Seq datasets to create a transcriptomic landscape of meningiomas, identifies subtypes with distinct biology and prognosis, and provides an interactive tool for outcome prediction.

bioRxiv · Feb 23, 2024Cancer Biology

Epigenetic reprogramming shapes the cellular landscape of schwannoma

S. J. Liu, T. Casey-Clyde, N. W. Cho, J. Swinderman, M. Pekmezci, M. C. Dougherty, K. Foster, W. C. Chen, J. E. Villanueva-Meyer, D. L. Swaney, H. N. Vasudevan, A. Choudhury, J. D. Breshears, U. E. Lang, C. D. Eaton, , D. R. Raleigh

This study identifies two molecular groups in schwannomas driven by epigenetic reprogramming and shows ionizing radiation can reprogram neural crest to immune-enriched schwannomas.

Nature Communications · Jan 12, 2024Peer-reviewedCancer Biology

Glioma-neuronal circuit remodeling induces regional immunosuppression

T. Nejo, S. Krishna, C. Jimenez, A. Yamamichi, J. S. Young, S. Lakshmanachetty, T. Chen, S. S. S. Phyu, H. Ogino, P. Watchmaker, D. Diebold, A. Choudhury, A. G. S. Daniel, D. R. Raleigh, S. L. Hervey-Jumper, H. Okada

This study shows that glioma-induced neuronal circuit remodeling creates regional immunosuppression in glioblastomas by altering tumor-associated macrophages and T-cell infiltration.

bioRxiv · Aug 4, 2023Cancer Biology

NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy

A. Choudhury, M. A. Cady, C.-H. G. Lucas, H. Najem, J. J. Phillips, B. Palikuqi, N. Zakimi, T. Joseph, J. O. Birreuta, W. C. Chen, N. A. O. Bush, S. L. Hervey-Jumper, O. D. Klein, C. M. Toedebusch, C. M. Horbinski, , D. R. Raleigh

This study identifies NOTCH3 as a driver of meningioma tumorigenesis and radiotherapy resistance, showing its role in tumor growth and survival in preclinical models.

bioRxiv · Jul 10, 2023 · PreprintCancer Biology

LncRNA Miat and Metadhedrin maintain a treatment resistant stem-like niche of medulloblastoma cells

K.-L. Peng, H. N. Vasudevan, D. T. Lockney, R. Baum, R. C. Hendrickson, D. R. Raleigh, A. M. Schmitt

This study identifies Miat and Metadhedrin as key regulators of treatment-resistant stem-like medulloblastoma cells, showing their role in maintaining a therapy-resistant niche.

bioRxiv · Sep 23, 2021 · PreprintCancer Biology

CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids

M. Lo, A. Sharir, M. D. Paul, H. Torosyan, C. Agnew, D. R. Raleigh, N. Jura, O. D. Klein

This study identifies CNPY4 as a negative regulator of the Hedgehog pathway by modulating membrane sterol lipid levels, revealing a new mechanism of pathway regulation.

bioRxiv · Mar 15, 2021Biochemistry